Local and systemic adverse effects of nanoparticles incorporated in dental materials- a critical review

Abstract

Introduction: Nanotechnology is the science and engineering of nanoparticles whose dimensions range from 1 to 100 nm. Nanoparticles have special characteristics like increased surface area, high reactivity, and enhanced mechanical, thermal, and optical properties that make them attractive for use in dental applications. However, the use of nanoparticles in dental materials can have toxic effects on the human body. The objective of this paper is to discuss the toxic effects of various nanoparticles in dental materials, their adverse effect on human health, and measures to overcome such effects. Objectives: Nanoparticles are used in the diagnosis, prevention, and treatment of oral diseases like dental caries, pulpo periodontal lesions, oral cancer, denture stomatitis, and candidiasis. Exposure to nanoparticles may occur to the dental professional, and the patient during procedures like restoration, finishing, and polishing. Such exposure to nanoparticles through inhalation, and ingestion causes toxic effects in the lungs, skin, brain, liver, and kidney. Proper risk assessment methods and preventive measures may help reduce these toxic effects to some extent. Significance: Toxic effects of nanoparticles that are released during dental procedures, their route of exposure, and the concentration at which nanoparticles can induce toxic effects on the human body are discussed in detail in this review. The paper also aims to create awareness among dental professionals, students, and patients regarding nanoparticle exposure and its adverse effects, and methods to prevent and overcome these effects. Currently, it is ignored or taken lightly by the stakeholders and this review may throw light.

Keywords

• Nanoparticle
• Adverse effects
• Dental materials
• Cytotoxicity
• Genotoxicity
• Risk assessment