Escuela de Química y Farmacia, Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile
Carolina Klagges
Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK, Facultad de Ciencias de la Salud, Universidad SEK, Santiago 8320000, Chile
Bernardo Morales
Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile
Paula Sotomayor
Departamento de Urología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile
Jorge Escobar
Laboratorio de Química Biológica, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile
Juan A. Fuentes
Laboratorio de Genética y Patogénesis Bacteriana, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8320000, Chile
Adrian A. Moreno
Centro de Biotecnología Vegetal, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8320000, Chile
Felipe M. Llancalahuen
Laboratorio de Fisiopatología Integrativa, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8320000, Chile
Ramiro Arratia-Perez
Center for Applied Nanoscience, Universidad Andrés Bello, Santiago 8320000, Chile
Felipe Gordillo-Fuenzalida
Laboratorio de Microbiología Aplicada, Centro de Biotecnología de los Recursos Naturales, Facultad de Ciencias Agrarias y Forestales, Universidad Católica del Maule, Talca 3460000, Chile
Michelle Herrera
Escuela de Química y Farmacia, Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile
Jose L. Martínez
Vicerrectoria de Investigación, Desarrollo e Innovación, Universidad de Santiago de Chile, Santiago 9160000, Chile
Maité Rodríguez-Díaz
Escuela de Química y Farmacia, Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile
Medicinal plants have been used since prehistoric times and continue to treat several diseases as a fundamental part of the healing process. Inflammation is a condition characterized by redness, pain, and swelling. This process is a hard response by living tissue to any injury. Furthermore, inflammation is produced by various diseases such as rheumatic and immune-mediated conditions, cancer, cardiovascular diseases, obesity, and diabetes. Hence, anti-inflammatory-based treatments could emerge as a novel and exciting approach to treating these diseases. Medicinal plants and their secondary metabolites are known for their anti-inflammatory properties, and this review introduces various native Chilean plants whose anti-inflammatory effects have been evaluated in experimental studies. Fragaria chiloensis, Ugni molinae, Buddleja globosa, Aristotelia chilensis, Berberis microphylla, and Quillaja saponaria are some native species analyzed in this review. Since inflammation treatment is not a one-dimensional solution, this review seeks a multidimensional therapeutic approach to inflammation with plant extracts based on scientific and ancestral knowledge.