Nature Communications (Oct 2021)

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

  • Paloma Cejas,
  • Yingtian Xie,
  • Alba Font-Tello,
  • Klothilda Lim,
  • Sudeepa Syamala,
  • Xintao Qiu,
  • Alok K. Tewari,
  • Neel Shah,
  • Holly M. Nguyen,
  • Radhika A. Patel,
  • Lisha Brown,
  • Ilsa Coleman,
  • Wenzel M. Hackeng,
  • Lodewijk Brosens,
  • Koen M. A. Dreijerink,
  • Leigh Ellis,
  • Sarah Abou Alaiwi,
  • Ji-Heui Seo,
  • Sylvan Baca,
  • Himisha Beltran,
  • Francesca Khani,
  • Mark Pomerantz,
  • Alessandra Dall’Agnese,
  • Jett Crowdis,
  • Eliezer M. Van Allen,
  • Joaquim Bellmunt,
  • Colm Morrisey,
  • Peter S. Nelson,
  • James DeCaprio,
  • Anna Farago,
  • Nicholas Dyson,
  • Benjamin Drapkin,
  • X. Shirley Liu,
  • Matthew Freedman,
  • Michael C. Haffner,
  • Eva Corey,
  • Myles Brown,
  • Henry W. Long

DOI
https://doi.org/10.1038/s41467-021-26042-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.