Amide proton transfer imaging of Alzheimer's disease and Parkinson's disease

Chunmei Li; Jinyuan Zhou; Di Wang; Xinyang Li; Shanshan Jiang; Yi Zhang; Zhibo Wen; Guangbin Wang; Fuhua Yan; Min Chen

Magnetic Resonance Letters (Feb 2023)

Amide proton transfer imaging of Alzheimer's disease and Parkinson's disease

Chunmei Li,
Jinyuan Zhou,
Di Wang,
Xinyang Li,
Shanshan Jiang,
Yi Zhang,
Zhibo Wen,
Guangbin Wang,
Fuhua Yan,
Min Chen

Affiliations

Chunmei Li: Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China
Jinyuan Zhou: Department of Radiology, Johns Hopkins University, Baltimore, MD, 21287, USA
Di Wang: Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China
Xinyang Li: Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China
Shanshan Jiang: Department of Radiology, Johns Hopkins University, Baltimore, MD, 21287, USA
Yi Zhang: Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, 310027, China
Zhibo Wen: Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China
Guangbin Wang: Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China
Fuhua Yan: Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China
Min Chen: Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China; Corresponding author. Department of Radiology, Beijing Hospital, No. 1 Da-Hua Road, Dong Dan, Beijing, 100730, China.

Journal volume & issue: Vol. 3, no. 1
pp. 22 – 30

Abstract

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Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecular imaging technique at the protein level in tissue. Neurodegenerative diseases have a high likelihood of causing abnormal protein accumulation in the brain, which can be detected by APT MRI. This article briefly introduces the principles and image processing technology of APT MRI, and reviews the current state of research on Alzheimer's disease and Parkinson's disease using this technique. Early applications of this approach in these two neurodegenerative diseases are encouraging, which also suggests continued technical development and larger clinical trials to gauge the value of this technique.

Published in Magnetic Resonance Letters

ISSN: 2097-0048 (Print); 2772-5162 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Science: Chemistry: Physical and theoretical chemistry; Science: Chemistry: Analytical chemistry
Website: https://www.keaipublishing.com/en/journals/magnetic-resonance-letters/

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Abstract

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