Frontiers in Oncology (Sep 2020)

Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report

  • Paolo Salvioni Chiabotti,
  • Bettina Bisig,
  • Anne Cairoli,
  • Steven D. Hajdu,
  • Pierre-Yves Lovey,
  • Dina Milowich,
  • Sonia Ziadi,
  • Renaud Du Pasquier,
  • Jean-Philippe Brouland,
  • Laurence de Leval

DOI
https://doi.org/10.3389/fonc.2020.01745
Journal volume & issue
Vol. 10

Abstract

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Central nervous system involvement in Hodgkin lymphoma is extremely rare, especially in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), which usually carries a favorable prognosis. Here we report a case of a young patient with NLPHL, who developed a progressive and fatal neurological deterioration requiring a very extensive work-up including two biopsies to obtain the diagnosis of T-cell/histiocyte-rich large B-cell lymphoma like transformation. This report, which includes post-mortem analysis, highlights the correlations between clinical, radiological, and biological data but also the difficulties encountered in reaching the correct diagnosis.

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