Nature Communications (Aug 2018)
MAIT cells protect against pulmonary Legionella longbeachae infection
- Huimeng Wang,
- Criselle D’Souza,
- Xin Yi Lim,
- Lyudmila Kostenko,
- Troi J. Pediongco,
- Sidonia B. G. Eckle,
- Bronwyn S. Meehan,
- Mai Shi,
- Nancy Wang,
- Shihan Li,
- Ligong Liu,
- Jeffrey Y. W. Mak,
- David P. Fairlie,
- Yoichiro Iwakura,
- Jennifer M. Gunnersen,
- Andrew W. Stent,
- Dale I. Godfrey,
- Jamie Rossjohn,
- Glen P. Westall,
- Lars Kjer-Nielsen,
- Richard A. Strugnell,
- James McCluskey,
- Alexandra J. Corbett,
- Timothy S. C. Hinks,
- Zhenjun Chen
Affiliations
- Huimeng Wang
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Criselle D’Souza
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Xin Yi Lim
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Lyudmila Kostenko
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Troi J. Pediongco
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Sidonia B. G. Eckle
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Bronwyn S. Meehan
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Mai Shi
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Nancy Wang
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Shihan Li
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Ligong Liu
- Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
- Jeffrey Y. W. Mak
- Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
- David P. Fairlie
- Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland
- Yoichiro Iwakura
- Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
- Jennifer M. Gunnersen
- Anatomy and Neuroscience Department, University of Melbourne
- Andrew W. Stent
- Faculty of Veterinary and Agricultural Sciences, University of Melbourne
- Dale I. Godfrey
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Jamie Rossjohn
- Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Glen P. Westall
- Allergy Immunology and Respiratory Medicine, Alfred Hospital
- Lars Kjer-Nielsen
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Richard A. Strugnell
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- James McCluskey
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Alexandra J. Corbett
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Timothy S. C. Hinks
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Zhenjun Chen
- Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-018-05202-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.
