mSphere
(Feb 2021)
Antibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 Patients
Natalia Ruetalo,
Ramona Businger,
Karina Althaus,
Simon Fink,
Felix Ruoff,
Michaela Pogoda,
Angelika Iftner,
Tina Ganzenmüller,
Klaus Hamprecht,
Bertram Flehmig,
Tamam Bakchoul,
Markus F. Templin,
Michael Schindler
Affiliations
Natalia Ruetalo
Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
Ramona Businger
Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
Karina Althaus
Institute for Transfusion Medicine, University Hospital Tübingen, Tübingen, Germany
Simon Fink
NMI, Reutlingen, Germany
Felix Ruoff
NMI, Reutlingen, Germany
Michaela Pogoda
Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany
Angelika Iftner
Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
Tina Ganzenmüller
Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
Klaus Hamprecht
Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
Bertram Flehmig
Mediagnost GmbH, Reutlingen, Germany
Tamam Bakchoul
Institute for Transfusion Medicine, University Hospital Tübingen, Tübingen, Germany
Markus F. Templin
NMI, Reutlingen, Germany
Michael Schindler
ORCiD Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
DOI
https://doi.org/10.1128/mSphere.01145-20
Journal volume & issue
Vol. 6,
no. 1
Abstract
Read online
There is strong interest in the nature of the neutralizing antibody response against SARS-CoV-2 in infected individuals. For vaccine development, it is especially important which antibodies confer protection against SARS-CoV-2, if there is a phenomenon called antibody-dependent enhancement (ADE) of infection, and if there is cross-protection by antibodies directed against seasonal coronaviruses.
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