Nature Communications (Nov 2022)

The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis

  • Huimei Chen,
  • Gabriel Chew,
  • Nithya Devapragash,
  • Jui Zhi Loh,
  • Kevin Y. Huang,
  • Jing Guo,
  • Shiyang Liu,
  • Elisabeth Li Sa Tan,
  • Shuang Chen,
  • Nicole Gui Zhen Tee,
  • Masum M. Mia,
  • Manvendra K. Singh,
  • Aihua Zhang,
  • Jacques Behmoaras,
  • Enrico Petretto

DOI
https://doi.org/10.1038/s41467-022-34971-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 21

Abstract

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Non-ischemic cardiomyopathy is a severe disease, characterized by interstitial fibrosis in the left ventricle of the heart. Here authors show that the E3 ubiquitin ligase WWP2 plays a pathogenic role in heart fibrosis via regulating a distinct monocyte population that initiates the process.