In this paper, new oscillation conditions for the 2nd-order noncanonical neutral differential equation (a0t((ut+a1tug0t)′)β)′+a2tuβg1t=0, where t≥t0, are established. Using Riccati substitution and comparison with an equation of the first-order, we obtain criteria that ensure the oscillation of the studied equation. Furthermore, we complement and improve the previous results in the literature.