PLoS ONE (Jan 2013)

A decade of invasive meningococcal disease surveillance in Poland.

  • Anna Skoczyńska,
  • Izabela Waśko,
  • Alicja Kuch,
  • Marcin Kadłubowski,
  • Agnieszka Gołębiewska,
  • Małgorzata Foryś,
  • Marlena Markowska,
  • Patrycja Ronkiewicz,
  • Katarzyna Wasiak,
  • Aleksandra Kozińska,
  • Bożena Matynia,
  • Waleria Hryniewicz,
  • participants of of a laboratory-based surveillance of community acquired invasive bacterial infections (BINet)

DOI
https://doi.org/10.1371/journal.pone.0071943
Journal volume & issue
Vol. 8, no. 8
p. e71943

Abstract

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Neisseria meningitidis is a leading etiologic agent of severe invasive disease. The objective of the study was to characterise invasive meningococcal disease (IMD) epidemiology in Poland during the last decade, based on laboratory confirmed cases.The study encompassed all invasive meningococci collected between 2002 and 2011 in the National Reference Centre for Bacterial Meningitis. The isolates were re-identified and characterised by susceptibility testing, MLST analysis, porA and fetA sequencing. A PCR technique was used for meningococcal identification directly from clinical materials.In the period studied, 1936 cases of IMD were confirmed, including 75.6% identified by culture. Seven IMD outbreaks, affecting mostly adolescents, were reported; all were caused by serogroup C meningococci of ST-11. The highest incidence was observed among children under one year of age (15.71/100,000 in 2011). The general case fatality rate in the years 2010-2011 was 10.0%. Meningococci of serogroup B, C, Y and W-135 were responsible for 48.8%, 36.6%, 1.2% and 1.2% of cases, respectively. All isolates were susceptible to third generation cephalosporins, chloramphenicol, ciprofloxacin, and 84.2% were susceptible to penicillin. MLST analysis (2009-2011) revealed that among serogroup B isolates the most represented were clonal complexes (CC) ST-32CC, ST-18CC, ST-41/44CC, ST-213CC and ST-269CC, and among serogroup C: ST-103CC, ST-41/44CC and ST-11CC.The detection of IMD in Poland has changed over time, but observed increase in the incidence of the disease was mostly attributed to changes in the surveillance system including an expanded case definition and inclusion of data from non-culture diagnostics.