Nature Communications (Oct 2021)

Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment

  • Wu Zuo,
  • Guangming Chen,
  • Zhimei Gao,
  • Shuai Li,
  • Yanyan Chen,
  • Chenhui Huang,
  • Juan Chen,
  • Zhengjun Chen,
  • Ming Lei,
  • Qian Bian

DOI
https://doi.org/10.1038/s41467-021-26033-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

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During meiosis, chromosomes undergo dramatic changes in morphology and intranuclear positioning. Here the authors mapped the 3D genome architecture throughout mouse spermatogenesis by Hi-C of sorted cells to reveal the contributions of transcriptional activity and mechanical force in modulating homolog alignment and recombination.