Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

Kazuyuki Takata; Hiroki Takai; Yuta Yoshizaki; Takuya Nagata; Keisuke Kawahara; Yasuyuki Yoshida; Akinori Kuzuya; Yuichi Ohya

doi:10.3390/gels3040038

Gels (Oct 2017)

Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation

Kazuyuki Takata,
Hiroki Takai,
Yuta Yoshizaki,
Takuya Nagata,
Keisuke Kawahara,
Yasuyuki Yoshida,
Akinori Kuzuya,
Yuichi Ohya

Affiliations

Kazuyuki Takata: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
Hiroki Takai: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
Yuta Yoshizaki: Organization for Research and Development of Innovative Science and Technology (ORDIST), Kansai University, Suita, Osaka 564-8680, Japan
Takuya Nagata: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
Keisuke Kawahara: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
Yasuyuki Yoshida: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
Akinori Kuzuya: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan
Yuichi Ohya: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan

DOI: https://doi.org/10.3390/gels3040038
Journal volume & issue: Vol. 3, no. 4
p. 38

Abstract

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We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.

Published in Gels

ISSN: 2310-2861 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Inorganic chemistry; Science: Chemistry: General. Including alchemy
Website: http://www.mdpi.com/journal/gels

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