Nature Communications (Jun 2017)

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

  • Silvia Monteagudo,
  • Frederique M. F. Cornelis,
  • Carolina Aznar-Lopez,
  • Ploi Yibmantasiri,
  • Laura-An Guns,
  • Peter Carmeliet,
  • Frédéric Cailotto,
  • Rik J. Lories

DOI
https://doi.org/10.1038/ncomms15889
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that inhibition of DOT1L can drive osteoarthritic disease in mice.