Frontiers in Cell and Developmental Biology (Aug 2015)

The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity

  • Stephanie eWallner,
  • Sebastian ePeters,
  • Claudia ePitzer,
  • Herbert eResch,
  • Herbert eResch,
  • Ulrich eBogdahn,
  • Armin eSchneider

DOI
https://doi.org/10.3389/fcell.2015.00048
Journal volume & issue
Vol. 3

Abstract

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Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.

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