Nature Communications (Jan 2018)
Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
Abstract
Duplexed aptamers are a common biosensor format; however, how complementary strand sequence, length, and position modulate ligand binding is not well understood. Here, the authors introduce ACE-Scan to comprehensively map binding landscapes, uncovering hotspots of enhanced binding by induced fit.