Nature Communications (Jan 2021)
Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma
- Phuong H. D. Nguyen,
- Siming Ma,
- Cheryl Z. J. Phua,
- Neslihan A. Kaya,
- Hannah L. H. Lai,
- Chun Jye Lim,
- Jia Qi Lim,
- Martin Wasser,
- Liyun Lai,
- Wai Leong Tam,
- Tony K. H. Lim,
- Wei Keat Wan,
- Tracy Loh,
- Wei Qiang Leow,
- Yin Huei Pang,
- Chung Yip Chan,
- Ser Yee Lee,
- Peng Chung Cheow,
- Han Chong Toh,
- Florent Ginhoux,
- Shridhar Iyer,
- Alfred W. C. Kow,
- Yock Young Dan,
- Alexander Chung,
- Brian K. P. Goh,
- Salvatore Albani,
- Pierce K. H. Chow,
- Weiwei Zhai,
- Valerie Chew
Affiliations
- Phuong H. D. Nguyen
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Siming Ma
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Cheryl Z. J. Phua
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Neslihan A. Kaya
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Hannah L. H. Lai
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Chun Jye Lim
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Jia Qi Lim
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Martin Wasser
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Liyun Lai
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Wai Leong Tam
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Tony K. H. Lim
- Department of Pathology, Singapore General Hospital
- Wei Keat Wan
- Department of Pathology, Singapore General Hospital
- Tracy Loh
- Department of Pathology, Singapore General Hospital
- Wei Qiang Leow
- Department of Pathology, Singapore General Hospital
- Yin Huei Pang
- Department of Pathology, National University Hospital Singapore
- Chung Yip Chan
- Duke-NUS Medical School
- Ser Yee Lee
- Duke-NUS Medical School
- Peng Chung Cheow
- Duke-NUS Medical School
- Han Chong Toh
- Duke-NUS Medical School
- Florent Ginhoux
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Shridhar Iyer
- Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital Singapore
- Alfred W. C. Kow
- Department of Medicine, Yong Loo Lin School of Medicine, National University Hospital Singapore
- Yock Young Dan
- Division of Gastroenterology and Hepatology, National University Hospital Singapore
- Alexander Chung
- Duke-NUS Medical School
- Brian K. P. Goh
- Duke-NUS Medical School
- Salvatore Albani
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- Pierce K. H. Chow
- Duke-NUS Medical School
- Weiwei Zhai
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Valerie Chew
- Translational Immunology Institute (TII), SingHealth-DukeNUS Academic Medical Centre
- DOI
- https://doi.org/10.1038/s41467-020-20171-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.
