Is PSA Still the Best Predictor for Biochemical Recurrence after Radical Prostatectomy in High-Risk Prostate Cancer?

Abstract

Background Patients with high-risk prostate cancer (PCa) experience heterogeneous oncological outcomes. In this study, we assessed the patients who underwent an RP procedure because of high-risk prostate cancer in subgroups formed according to D’Amico criteria and analyzed the effects of these criteria on biochemical recurrence (BCR) after RP. Methods We retrospectively identified high-risk non-metastatic PCa patients who underwent RP between 2006 and 2020 in our hospital. Groups were formed as follows: group 1 consisted of those with an ISUP grade 4 − 5 biopsy, group 2 consisted of those with a clinical stage T2c, group 3 consisted of those with a tPSA level ≥ 20 ng/ml, and group 4 consisted of those with locally advanced disease. Survival analyses were made by Kaplan–Meier test and Log Rank test. A P value 0.05). Conclusion Despite the developments in the imaging technology, an elevated tPSA level remains to be an important predictor for BCR-free survival.

Keywords

• biochemical recurrence
• biochemistry
• cancer
• prostate cancer
• prostate specific antigen
• high-risk
• radical prostatectomy
• urology