Heliyon (Dec 2020)
Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis
- José Avendaño-Ortiz,
- Roberto Lozano-Rodríguez,
- Alejandro Martín-Quirós,
- Charbel Maroun-Eid,
- Verónica Terrón,
- Jaime Valentín,
- Karla Montalbán-Hernández,
- Fátima Ruiz de la Bastida,
- Miguel A. García-Garrido,
- Carolina Cubillos-Zapata,
- Álvaro del Balzo-Castillo,
- Luis A. Aguirre,
- Eduardo López-Collazo
Affiliations
- José Avendaño-Ortiz
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Roberto Lozano-Rodríguez
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Alejandro Martín-Quirós
- Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Charbel Maroun-Eid
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Verónica Terrón
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Jaime Valentín
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Karla Montalbán-Hernández
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Fátima Ruiz de la Bastida
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Miguel A. García-Garrido
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Carolina Cubillos-Zapata
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain
- Álvaro del Balzo-Castillo
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Emergency Department and Emergent Pathology Research Group, IdiPAZ La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain
- Luis A. Aguirre
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Corresponding author.
- Eduardo López-Collazo
- The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; Tumor Immunology Laboratory, IdiPAZ, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain; CIBER of Respiratory Diseases (CIBERES), Madrid, Spain; Corresponding author.
- Journal volume & issue
-
Vol. 6,
no. 12
p. e05635
Abstract
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.