Фармакокинетика и Фармакодинамика (Apr 2013)

Bioequivalence of bisoprolol, coated tablets 10 mg JSC «Chimpharm» Republic of Kazakhstan

  • Y. M. Budach,
  • O. E. Kurilo,
  • A. K. Sariev,
  • D. A. Abaimov,
  • M. V. Shiryaev,
  • E. Y. Styrova,
  • S. A. Altynbekov,
  • G. A. Dzholdygulov,
  • V. N. Seryakov,
  • K. S. Altynbekov

Journal volume & issue
Vol. 0, no. 1
pp. 27 – 34

Abstract

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Within the cross, a single, open, randomized study with 10 day washout period, the two sequences has been studied bioequivalence of tablet forms two bisoprolol 18 volunteers (10 mg dosage). Plasma samples were analyzed by a validated HPLC-MS/MS within 48 hours. For preparations analyzed following pharmacokinetic parameters were calculated: AUC0-t, Cmax, Tmax , Cmax /AUC. 90% confidence interval for log-transformed values for AUC0-t was 0.9142—1.0568 for Cmax —0,9371 —1,0473. The study concluded that comparable drugs were bioequivalence of bisoprolol.

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