Corticobasal syndrome as a phenotype of various neurodegenerative disorders: a case series

Abstract

Corticobasal syndrome (CBS) is a variant of atypical parkinsonism. The underlying cause may be corticobasal degeneration or other proteinopathies, which can be verified only after studying specific biomarkers. The disease aetiology in CBS needs to be established to determine the disease prognosis. It can also affect the choice of pathogenetic treatment due to the differences in the molecular pathogenesis of proteinopathies that cause neurodegenerative processes. Four clinical cases of CBS are presented: in patients with four-repeat tauopathy, Alzheimer's disease, frontotemporal dementia and CreutzfeldtJakob disease. Examples are provided of the clinical, genetic and biochemical biomarkers available for differential diagnosis of CBS.

Keywords

• corticobasal syndrome
• corticobasal degeneration
• creutzfeldt-jakob disease
• alzheimer's disease
• four-repeat tauopathy