Investigation of rat progenitor neural cells supernatant antitumor action on glioma cells in conditions of culture

Abstract

The purpose was to investigate rat progenitor neurocells E12–16 supernatant action on the growth activity of glial tumors in conditions of culture. The dose-dependent effect of neurocells E12–16 supernatant antitumor influence intensification was registered following 24-hour incubation with anaplastic glioma cultures. After incubation with neurocells E12–16 supernatant the dystrophic and necrobiotic changes in most tumor cells with disturbance of general structure of the cells growth area were observed intensifying under prolongated incubation to 48 hours. Neurocells E12–16 supernatant effects depended on the degree of tumor anaplasia. The most significant antitumor effect of the neurocells supernatant was registered in glioblastoma cultures.