BMJ Neurology Open (Aug 2022)
Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid
- ,
- Takashi Sakurai,
- Kengo Ito,
- Koichi Kozaki,
- Kenji Toba,
- Hiroshige Fujishiro,
- Masanori Nakagawa,
- Kazuo Ogawa,
- Hiroshi Yamauchi,
- Chio Okuyama,
- Hiroshi Ito,
- Daisuke Watanabe,
- Satoshi Koyama,
- Ryosuke Takahashi,
- Kazunori Terasaki,
- Harushi Mori,
- Tetsuya Maeda,
- Masaru Suzuki,
- Masatoyo Nishizawa,
- Mikio Shoji,
- Mineo Yamazaki,
- Etsuro Matsubara,
- Shuichi Ikeda,
- Hidehiro Mizusawa,
- Kenji Nakashima,
- Jun Takeuchi,
- Hiroyuki Shimada,
- Takashi Kudo,
- Nobuyuki Saito,
- Hiroyuki Arai,
- Takashi Yamazaki,
- Mitsutoshi Okazaki,
- Takeshi Iwatsubo,
- Nobuo Sanjo,
- Masaki Takao,
- Shigeo Murayama,
- Masahito Yamada,
- Yuichi Sato,
- Satoshi Takahashi,
- Harumasa Takano,
- Masuhiro Sakata,
- Shunji Mugikura,
- Shun Shimohama,
- Takashi Kato,
- Toshiki Mizuno,
- Yukiko Yamada,
- Daisuke Yamamoto,
- Makoto Higuchi,
- Yu Nakamura,
- Yu Hayasaka,
- Yoshiko Fukushima,
- Takayuki Obata,
- Kimiko Yoshimaru,
- Shinichi Sakamoto,
- Kaori Watanabe,
- Masashi Tsujimoto,
- Osamu Yokota,
- Seishi Terada,
- Atsushi Watanabe,
- Akinori Miyashita,
- Ryozo Kuwano,
- Daisuke Yamaguchi,
- Tetsuaki Arai,
- Rieko Okada,
- Hiroshi Matsuda,
- Kyoko Ito,
- Kenji Ishii,
- Yukio Miki,
- Yuka Yamamoto,
- Toru Takahashi,
- Makoto Sasaki,
- Ken Nagata,
- Hajime Sato,
- Miwako Takahashi,
- Toshimitsu Momose,
- Isao Ito,
- Masakazu Yamagishi,
- Mayumi Watanabe,
- Hitoshi Shibuya,
- Shin-ichi Urayama,
- Hidenao Fukuyama,
- Toshio Kawamata,
- Yasuji Yamamoto,
- Kiyoshi Maeda,
- Manabu Ikeda,
- Mamoru Hashimoto,
- Takeshi Kawarabayashi,
- Masaki Ikeda,
- Eizo Iseki,
- Kazunari Ishii,
- Yuko Saito,
- Miharu Samuraki,
- Heii Arai,
- Takashi Asada,
- Haruo Hanyu,
- Katsuyoshi Mizukami,
- Takahiko Tokuda,
- Yukihiko Washimi,
- Mitsuhiro Yoshita,
- Hitoshi Shimada,
- Fumitoshi Niwa,
- Hitoshi Shinotoh,
- Tetsuya Suhara,
- Masatoshi Takeda,
- YOKO KONAGAYA,
- Takaaki Mori,
- Kensaku Kasuga,
- Takayoshi Tokutake,
- Takeshi Ikeuchi,
- Hiroaki Kazui,
- Noriko Sato,
- Takeshi Tamaru,
- Masanobu Takahashi,
- Yasuhiro Nakata,
- Yasumasa Yoshiyama,
- Hisatomo Kowa,
- Shuichi Ono,
- Takuya Ohkubo,
- Yasuo Kuwabara,
- Tomoko Nakazawa,
- Kazutomi Kanemaru,
- Toshiaki Taoka,
- Nobuyuki Okamura,
- Hiroki Hayashi,
- Shin Tanaka,
- Kayoko Kikuchi,
- Masataka Kikuchi,
- Tamao Tsukie,
- Kazushi Suzuki,
- Ryoko Ihara,
- Atsushi Iwata,
- Norikazu Hara,
- Morihiro Sugishita,
- Michio Senda,
- Masaki Saitoh,
- Rika Yamauchi,
- Takashi Hayashi,
- Seiju Kobayashi,
- Norihito Nakano,
- Junichiro Kanazawa,
- Takeshi Ando,
- Chiyoko Takanami,
- Masato Hareyama,
- Masamitsu Hatakenaka,
- Eriko Tsukamoto,
- Shinji Ochi,
- Yasuhito Wakasaya,
- Takashi Nakata,
- Naoko Nakahata,
- Yoshihiro Takai,
- Hisashi Yonezawa,
- Junko Takahashi,
- Masako Kudoh,
- Yutaka Matsumura,
- Yohsuke Hirata,
- Tsuyoshi Metoki,
- Susumu Hayakawa,
- Masayuki Takeda,
- Toshiaki Sasaki,
- Koichiro Sera,
- Yoshihiro Saitoh,
- Shoko Goto,
- Kuniko Ueno,
- Hiromi Sakashita,
- Kuniko Watanabe,
- Yasushi Kondoh,
- Daiki Takano,
- Mio Miyata,
- Hiromi Komatsu,
- Tomomi Sinoda,
- Rena Muraoka,
- Hitomi Ito,
- Aki Sato,
- Toshibumi Kinoshita,
- Hideyo Toyoshima,
- Kaoru Sato,
- Shigeki Sugawara,
- Fumiko Kumagai,
- Katsutoshi Furukawa,
- Masaaki Waragai,
- Naoki Tomita,
- Mari Ootsuki,
- Katsumi Sugawara,
- Satomi Sugawara,
- Atsushi Umetsu,
- Takanori Murata,
- Tatsuo Nagasaka,
- Yukitsuka Kudo,
- Manabu Tashiro,
- Shoichi Watanuki,
- Saeri Ishikawa,
- Emiko Kishida,
- Nozomi Sato,
- Mieko Hagiwara,
- Kumi Yamanaka,
- Takeyuki Watanabe,
- Taeko Takasugi,
- Shoichi Inagawa,
- Kenichi Naito,
- Masanori Awaji,
- Tsutomu Kanazawa,
- Kouiti Okamoto,
- Tsuneo Yamazaki,
- Yuiti Tasiro,
- Syunn Nagamine,
- Shiori Katsuyama,
- Sathiko Kurose,
- Sayuri Fukushima,
- Etsuko Koya,
- Makoto Amanuma,
- Noboru Oriuti,
- Kouiti Ujita,
- Kazuhiro Kishi,
- Kazuhisa Tuda,
- Etsuko Nakajima,
- Katsumi Miyamoto,
- Kousaku Saotome,
- Tomoya Kobayashi,
- Saori Itoya,
- Jun Ookubo,
- Toshiya Akatsu,
- Yoshiko Anzai,
- Junya Ikegaki,
- Yuuichi Katou,
- Kaori Kimura,
- Ryou Kuchii,
- Hajime Saitou,
- Kazuya Shinoda,
- Satoka Someya,
- Hiroko Taguchi,
- Kazuya Tashiro,
- Masaya Tanaka,
- Tatsuya Nemoto,
- Ryou Wakabayashi,
- Hitoshi Shinoto,
- Kazuko Suzuki,
- Izumi Izumida,
- Katsuyuki Tanimoto,
- Takahiro Shiraishi,
- Junko Shiba,
- Hiroaki Yano,
- Miki Satake,
- Aimi Nakui,
- Yae Ebihara,
- Tomomi Hasegawa,
- Mami Kato,
- Yuki Ogata,
- Hiroyuki Fujikawa,
- Nobuo Araki,
- Yoshihiko Nakazato,
- Takahiro Sasaki,
- Tomokazu Shimadu,
- Etsuko Imabayashi,
- Asako Yasuda,
- Etuko Yamamoto,
- Natsumi Nakamata,
- Noriko Miyauchi,
- Keiko Ozawa,
- Rieko Hashimoto,
- Taishi Unezawa,
- Takafumi Ichikawa,
- Tunemichi Mihara,
- Masaya Hirano,
- Shinichi Watanabe,
- Junichiro Fukuhara,
- Hajime Matsudo,
- Toshihiro Hayashi,
- Toji Miyagawa,
- Mizuho Yoshida,
- Yuri Koide,
- Eriko Samura,
- Kurumi Fujii,
- Nagae Orihara,
- Akira Kunimatsu,
- Takuya Arai,
- Yoshiki Kojima,
- Masami Goto,
- Takeo Sarashina,
- Syuichi Uzuki,
- Seiji Katou,
- Yoshiharu Sekine,
- Yukihiro Takauchi,
- Chiine Kagami,
- Yasushi Nishina,
- Maria Sakaibara,
- Yumiko Okazaki,
- Maki Obata,
- Yuko Iwata,
- Mizuho Minami,
- Yasuko Hanabusa,
- Hanae Shingyouji,
- Kyoko Tottori,
- Aya Tokumaru,
- Makoto Ichinose,
- Kazuya Kume,
- Syunsuke Kahashi,
- Kunimasa Arima,
- Tadashi Tukamoto,
- Yuko Nagahusa,
- Maki Yamada,
- Tiine Kodama,
- Tomoko Takeuchi,
- Keiichiro Ozawa,
- Yoshiko Kawaji,
- Kyouko Tottori,
- Satoshi Sawada,
- Makoto Mimatsu,
- Daisuke Nakkamura,
- Shunichirou Horiuchi,
- Tsuneyoshi Ota,
- Aiko Kodaka,
- Yuko Tagata,
- Tomoko Nakada,
- Kiyoshi Sato,
- Norio Murayama,
- Satoshi Kimura,
- Hirofumi Sakurai,
- Takahiko Umahara,
- Hidekazu Kanetaka,
- Kaori Arashino,
- Mikako Murakami,
- Ai Kito,
- Seiko Miyagi,
- Kaori Doi,
- Kazuyoshi Sasaki,
- Akiko Ishiwata,
- Yasushi Arai,
- Akane Nogami,
- Sumiko Fukuda,
- Sayaka Kimura,
- Ayako Machida,
- Kuninori Kobayashi,
- Mutsufusa Watanabe,
- Hiromi Utashiro,
- Yukiko Matsumoto,
- Kumiko Hagiya,
- Yoshiko Miyama,
- Takako Shinozaki,
- Haruko Hiraki,
- Isamu Ohashi,
- Akira Toriihara,
- Shinichi Ohtani,
- Toshifumi Matsui,
- Tomomi Toyama,
- Hideki Sakurai,
- Kumiko Sugiura,
- Hirofumi Taguchi,
- Shizuo Hatashita,
- Akari Imuta,
- Akiko Matsudo,
- Daichi Wakebe,
- Hideki Hayakawa,
- Mitsuhiro Ono,
- Takayoshi Ohara,
- Yutaka Arahata,
- Akinori Takeda,
- Akiko Yamaoka,
- Hideyuki Hattori,
- Miura Hisayuki,
- Hidetoshi Endou,
- Syousuke Satake,
- Young Jae Hong,
- Katsunari Iwai,
- Kenji Yoshiyama,
- Masaki Suenaga,
- Sumiko Morita,
- Teruhiko Kachi,
- Rina Miura,
- Takiko Kawai,
- Ai Honda,
- Kengo Itou,
- Ken Fujiwara,
- Rikio Katou,
- Mariko Koyama,
- Naohiko Fukaya,
- Akira Tsuji,
- Hitomi Shimizu,
- Hiroyuki Fujisawa,
- Takanori Sakata,
- Kenjiro Ono,
- Moeko Shinohara,
- Yuki Soshi,
- Kozue Niwa,
- Chiaki Doumoto,
- Mariko Hata,
- Miyuki Matsushita,
- Mai Tsukiyama,
- Nozomi Takeda,
- Sachiko Yonezawa,
- Ichiro Matsunari,
- Osamu Matsui,
- Fumiaki Ueda,
- Yasuji Ryu,
- Masanobu Sakamoto,
- Yasuomi Ouchi,
- Madoka Chita,
- Yumiko Fujita,
- Rika Majima,
- Hiromi Tsubota,
- Umeo Shirasawa,
- Masashi Sugimori,
- Wataru Ariya,
- Yuuzou Hagiwara,
- Yasuo Tanizaki,
- Hajime Takechi,
- Chihiro Namiki,
- Kengo Uemura,
- Takeshi Kihara,
- Shizuko Tanaka-Urayama,
- Emiko Maeda,
- Natsu Saito,
- Shiho Satomi,
- Konomi Kabata,
- Tomohisa Okada,
- Koichi Ishizu,
- Shigeto Kawase,
- Satoshi Fukumoto,
- Masaki Kondo,
- Yoko Oishi,
- Mariko Yamazaki,
- Yoku Asano,
- Chizuru Hamaguchi,
- Kei Yamada,
- Kentaro Akazawa,
- Shigenori Matsushima,
- Takamasa Matsuo,
- Toshiaki Nakagawa,
- Takeshi Nii,
- Takuji Nishida,
- Kuniaki Kiuchi,
- Masami Fukusumi,
- Hideyuki Watanabe,
- Akihiro Nogi,
- Toshihisa Tanaka,
- Naoyuki Sato,
- Masayasu Okochi,
- Takashi Morihara,
- Shinji Tagami,
- Noriyuki Hayashi,
- Masahiko Takaya,
- Tamiki Wada,
- Mikiko Yokokoji,
- Hiromichi Sugiyama,
- Shuko Takeda,
- Keiko Nomura,
- Mutsumi Tomioka,
- Eiichi Uchida,
- Yoshiyuki Ikeda,
- Mineto Murakami,
- Takami Miki,
- Suzuka Ataka,
- Motokatsu Kanemoto,
- Akitoshi Takeda,
- Rie Azuma,
- Yuki Iwamoto,
- Naomi Tagawa,
- Junko Masao,
- Yuka Matsumoto,
- Yuko Kikukawa,
- Hisako Fujii,
- Junko Matsumura,
- Susumu Shiomi,
- Joji Kawabe,
- Yoshihiro Shimonishi,
- Mitsuji Higashida,
- Tomohiro Sahara,
- Takashi Yamanaga,
- Hiroyuki Tsushima,
- Kazuo Sakai,
- Haruhiko Oda,
- Taichi Akisaki,
- Mizuho Adachi,
- Masako Kuranaga,
- Sachi Takegawa,
- Yoshihiko Tahara,
- Takeshi Ishihara,
- Hajime Honda,
- Yuki Kishimoto,
- Naoya Takeda,
- Nao Imai,
- Mayumi Yabe,
- Kentaro Ida,
- Daigo Anami,
- Seiji Inoue,
- Toshi Matsushita,
- Reiko Wada,
- Shinsuke Hiramatsu,
- Hiromi Tonbara,
- Reiko Yamamoto,
- Kenji Wada-Isoe,
- Saori Yamasaki,
- Eijiro Yamashita,
- Ichiro Ishikawa,
- Sonoko Danjo,
- Tomomi Shinohara,
- Miyuki Ueno,
- Yuka Kashimoto,
- Yoshihiro Nishiyama,
- Narihide Kimura,
- Yasuhiro Sasakawa,
- Takashi Ishimori,
- Yukito Maeda,
- Tatsuo Yamada,
- Shinji Ouma,
- Aika Fukuhara-Kaneumi,
- Nami Sakamoto,
- Rie Nagao,
- Kengo Yoshimitsu,
- Ryuji Nakamuta,
- Minoru Tanaka,
- Keiichirou Kaneda,
- Yuusuke Yatabe,
- Kazuki Honda,
- Naoko Ichimi,
- Fumi Akatuka,
- Mariko Morinaga,
- Miyako Noda,
- Mika Kitajima,
- Toshinori Hirai,
- Shinya Shiraishi,
- Naoji Amano,
- Shinsuke Washizuka,
- Shin Inuzuka,
- Tetsuya Hagiwara,
- Nobuhiro Sugiyama,
- Yatsuka Okada,
- Tomomi Ogihara,
- Takehiko Yasaki,
- Minori Kitayama,
- Tomonori Owa,
- Akiko Ryokawa,
- Rie Takeuchi,
- Satoe Goto,
- Keiko Yamauchi,
- Mie Ito,
- Tomoki Kaneko,
- Hitoshi Ueda,
- Ban Mihara,
- Hirofumi Kubo,
- Akiko Takano,
- Gou Yasui,
- Masami Akuzawa,
- Kaori Yamaguchi,
- Toshinari Odawara,
- Megumi Shimamura,
- Mikiko Sugiyama,
- Naomi Oota,
- Shigeo Takebayashi,
- Yoshigazu Hayakawa,
- Mitsuhiro Idegawa,
- Noriko Toya
Affiliations
- Takashi Sakurai
- 1 Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan
- Kengo Ito
- 3 Innovation Center for Clinical Research, National Center for Geriatrics and Gerontology, Obu, Japan
- Koichi Kozaki
- 9 Department of Geriatric Medicine, Kyorin University School of Medicine, Tokyo, Japan
- Kenji Toba
- 1 Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan
- Hiroshige Fujishiro
- Department of Psychiatry, Kawasaki Memorial Hospital, Kawasaki, Japan
- Masanori Nakagawa
- 2 North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Kazuo Ogawa
- Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
- Hiroshi Yamauchi
- Division of PET Imaging, Shiga Medical Center Research Institute, Moriyama, Japan
- Chio Okuyama
- Division of PET Imaging, Shiga Medical Center Research Institute, Moriyama, Japan
- Hiroshi Ito
- Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
- Daisuke Watanabe
- 49 Stroke and Neurovascular Surgery, IMS Tokyo-Katsushika General Hospital, Tokyo, Japan
- Satoshi Koyama
- 1 Department of Emergency Medicine, Okinawa Prefectural Chubu Hospital, Uruma, Okinawa, Japan
- Ryosuke Takahashi
- Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
- Kazunori Terasaki
- 2 Cyclotron Research Center, Iwate Medical University, Morioka, Japan
- Harushi Mori
- Radiology, The University of Tokyo, Tokyo, Japan
- Tetsuya Maeda
- Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Morioka, Japan
- Masaru Suzuki
- 1 First Department of Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
- Masatoyo Nishizawa
- Brain Research Institute, Niigata University, Niigata, Japan
- Mikio Shoji
- Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and Department of Neurological Science, Institute of Brain Science, Hirosaki University School of Medicine, Aomori, Japan
- Mineo Yamazaki
- Division of Neurology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
- Etsuro Matsubara
- Department of Alzheimer’s Disease Research, National Institute of Longevity Sciences, National Center for Geriatrics and Gerontology, Aichi, Japan
- Shuichi Ikeda
- Hidehiro Mizusawa
- 10 Department of Neurology, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan
- Kenji Nakashima
- 16 Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Tottori, Japan
- Jun Takeuchi
- 3 Sapporo Diabetes and Thyroid Clinic, Sapporo, Hokkaido, Japan
- Hiroyuki Shimada
- 1 Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
- Takashi Kudo
- 3Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
- Nobuyuki Saito
- Shock and Trauma Center, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan
- Hiroyuki Arai
- 1 Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
- Takashi Yamazaki
- Mitsutoshi Okazaki
- Department of Psychiatry, National Centre Hospital for Mental, Nervous and Muscular Disorders, NCNP, Kodaira, Japan
- Takeshi Iwatsubo
- Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan
- Nobuo Sanjo
- 2 Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan
- Masaki Takao
- 4 Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Japan
- Shigeo Murayama
- 5 Department of Neurology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
- Masahito Yamada
- 1 Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
- Yuichi Sato
- Takasaki Art Clinic, Takasaki, Gunma, Japan
- Satoshi Takahashi
- Department of Hematology/Oncology, The Institute of Medical Science The University of Tokyo, Tokyo, Japan
- Harumasa Takano
- Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
- Masuhiro Sakata
- Department of Psychiatry, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
- Shunji Mugikura
- Department of Diagnostic Radiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
- Shun Shimohama
- Department of Neurology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
- Takashi Kato
- Department of general surgery, Okinawa Prefectural Chubu Hospital, Uruma, Okinawa, Japan
- Toshiki Mizuno
- 2 Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Yukiko Yamada
- Department of Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
- Daisuke Yamamoto
- Department of Neurology, Shonan Kamakura General Hospital, Kamakura, Japan
- Makoto Higuchi
- 1 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
- Yu Nakamura
- Department of Urology, Kyorin University School of Medicine, Tokyo, Japan
- Yu Hayasaka
- 1Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan
- Yoshiko Fukushima
- 2Department of Nursing, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
- Takayuki Obata
- 1Hospital of the National Institute of Radiological Sciences, National Institutes of Quantum and Radiation Science and Technology, Chiba, Japan
- Kimiko Yoshimaru
- Dementia Prevention and Therapeutics, Mie University Graduate School of Medicine Faculty of Medicine, Tsu, Japan
- Shinichi Sakamoto
- 1 Department of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, Japan
- Kaori Watanabe
- Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
- Masashi Tsujimoto
- Japan National Center for Geriatrics & Gerontology, Obu, Japan
- Osamu Yokota
- Department of Neuropsychiatry, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan
- Seishi Terada
- Department of Neuropsychiatry, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan
- Atsushi Watanabe
- 1Department of Pediatrics, University of Yamanashi, Chuo-city, Yamanashi, Japan
- Akinori Miyashita
- Department of Molecular Genetics, Center for Bioresource-based Researches, Brain Research Institute, Niigata University, Japan
- Ryozo Kuwano
- Department of Molecular Genetics, Center for Bioresource-based Researches, Brain Research Institute, Niigata University, Japan
- Daisuke Yamaguchi
- 1Department of Gastroenterology, Osaka Saiseikai Senri Hospital, Suita, Osaka, Japan
- Tetsuaki Arai
- 2 Department of Psychiatry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
- Rieko Okada
- 12Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
- Hiroshi Matsuda
- 3Japan Psychiatric Hospital Association, Tokyo, Japan
- Kyoko Ito
- Postmarketing Surveillance Committee of the Japan College of Rheumatology, Tokyo, Japan
- Kenji Ishii
- Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
- Yukio Miki
- 1 Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
- Yuka Yamamoto
- Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine;
- Toru Takahashi
- Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan
- Makoto Sasaki
- Advanced Medical Science Center, Iwate Medical University, Morioka, Japan
- Ken Nagata
- Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
- Hajime Sato
- 2Department of Health Policy and Technology Assessment, National Institute of Public Health, Wako, Saitama, Japan
- Miwako Takahashi
- Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- Toshimitsu Momose
- Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- Isao Ito
- Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Masakazu Yamagishi
- Kanazawa University, Internal Medicine, Takaramachi 13-1, Kanazawa, 920-8640, Japan
- Mayumi Watanabe
- Department of Occupational Mental Health, Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan
- Hitoshi Shibuya
- 2Yuri Kumiai General Hospital, Japan
- Shin-ichi Urayama
- Human Brain Research Centre, Kyoto University Graduate School of Medicine, Kyoto, Japan
- Hidenao Fukuyama
- Human Brain Research Centre, Kyoto University Graduate School of Medicine, Kyoto, Japan
- Toshio Kawamata
- Yasuji Yamamoto
- Department of Biosignal Pathophysiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
- Kiyoshi Maeda
- Manabu Ikeda
- Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
- Mamoru Hashimoto
- Department of Psychiatry and Neuropathobiology, Kumamoto University, Kumamoto, Japan
- Takeshi Kawarabayashi
- Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
- Masaki Ikeda
- Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan
- Eizo Iseki
- 6 PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo, Japan
- Kazunari Ishii
- Department of Radiology, Kinki University, Sayama, Japan
- Yuko Saito
- Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan
- Miharu Samuraki
- 1 Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
- Heii Arai
- 3 Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
- Takashi Asada
- 5 Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
- Haruo Hanyu
- 7 Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
- Katsuyoshi Mizukami
- 12 Faculty of Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
- Takahiko Tokuda
- 19 Department of Molecular Pathobiology of Brain Diseases, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Yukihiko Washimi
- 22 Department for Cognitive Disorders, Hospital of National Center for Geriatrics and Gerontology, Toyota, Japan
- Mitsuhiro Yoshita
- 1 Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
- Hitoshi Shimada
- 1 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
- Fumitoshi Niwa
- 3 Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Hitoshi Shinotoh
- 1 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
- Tetsuya Suhara
- 1 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
- Masatoshi Takeda
- YOKO KONAGAYA
- Takaaki Mori
- 1Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
- Kensaku Kasuga
- Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
- Takayoshi Tokutake
- Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
- Takeshi Ikeuchi
- Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
- Hiroaki Kazui
- Noriko Sato
- 13 Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
- Takeshi Tamaru
- 13 Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
- Masanobu Takahashi
- 1Gastrointestinal Cancer Research Laboratory, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, USA
- Yasuhiro Nakata
- 4Department of Neuroradiology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
- Yasumasa Yoshiyama
- 1Clinical Research Centre, Chiba East National Hospital, Chiba, Chiba, Japan
- Hisatomo Kowa
- Division of Cognitive and Psychiatric Rehabilitation, Department of Rehabilitation Science, Kobe Univerity Graduate School of Health Sciences, Kobe, Hyogo, Japan
- Shuichi Ono
- Takuya Ohkubo
- Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan
- Yasuo Kuwabara
- Tomoko Nakazawa
- Department of Pediatrics, Seikeikai Chiba Medical Center, Chiba, Japan
- Kazutomi Kanemaru
- Department of Stroke, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
- Toshiaki Taoka
- Department of Innovative Biomedical Visualization, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
- Nobuyuki Okamura
- Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Hiroki Hayashi
- Nephrology, Fujita Health University, Toyoake, Japan
- Shin Tanaka
- Kayoko Kikuchi
- National Center for Child Health and Development, Center for Clinical Research and Development, Setagaya-ku, Tokyo, Japan
- Masataka Kikuchi
- Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan
- Tamao Tsukie
- Molecular Genetics, Niigata University Brain Research Institute, Niigata, Japan
- Kazushi Suzuki
- Neurology, National Defense Medical College, Tokorozawa, Japan
- Ryoko Ihara
- Neurology, Tokyo Metropolitan Geriatric Medical Center Hospital, Tokyo, Japan
- Atsushi Iwata
- Neurology, Tokyo Metropolitan Geriatric Medical Center Hospital, Tokyo, Japan
- Norikazu Hara
- Molecular Genetics, Niigata University Brain Research Institute, Niigata, Japan
- Morihiro Sugishita
- Michio Senda
- Masaki Saitoh
- Rika Yamauchi
- Takashi Hayashi
- Seiju Kobayashi
- Norihito Nakano
- Junichiro Kanazawa
- Takeshi Ando
- Chiyoko Takanami
- Masato Hareyama
- Masamitsu Hatakenaka
- Eriko Tsukamoto
- Shinji Ochi
- Yasuhito Wakasaya
- Takashi Nakata
- Naoko Nakahata
- Yoshihiro Takai
- Hisashi Yonezawa
- Junko Takahashi
- Masako Kudoh
- Yutaka Matsumura
- Yohsuke Hirata
- Tsuyoshi Metoki
- Susumu Hayakawa
- Masayuki Takeda
- Toshiaki Sasaki
- Koichiro Sera
- Yoshihiro Saitoh
- Shoko Goto
- Kuniko Ueno
- Hiromi Sakashita
- Kuniko Watanabe
- Yasushi Kondoh
- Daiki Takano
- Mio Miyata
- Hiromi Komatsu
- Tomomi Sinoda
- Rena Muraoka
- Hitomi Ito
- Aki Sato
- Toshibumi Kinoshita
- Hideyo Toyoshima
- Kaoru Sato
- Shigeki Sugawara
- Fumiko Kumagai
- Katsutoshi Furukawa
- Masaaki Waragai
- Naoki Tomita
- Mari Ootsuki
- Katsumi Sugawara
- Satomi Sugawara
- Atsushi Umetsu
- Takanori Murata
- Tatsuo Nagasaka
- Yukitsuka Kudo
- Manabu Tashiro
- Shoichi Watanuki
- Saeri Ishikawa
- Emiko Kishida
- Nozomi Sato
- Mieko Hagiwara
- Kumi Yamanaka
- Takeyuki Watanabe
- Taeko Takasugi
- Shoichi Inagawa
- Kenichi Naito
- Masanori Awaji
- Tsutomu Kanazawa
- Kouiti Okamoto
- Tsuneo Yamazaki
- Yuiti Tasiro
- Syunn Nagamine
- Shiori Katsuyama
- Sathiko Kurose
- Sayuri Fukushima
- Etsuko Koya
- Makoto Amanuma
- Noboru Oriuti
- Kouiti Ujita
- Kazuhiro Kishi
- Kazuhisa Tuda
- Etsuko Nakajima
- Katsumi Miyamoto
- Kousaku Saotome
- Tomoya Kobayashi
- Saori Itoya
- Jun Ookubo
- Toshiya Akatsu
- Yoshiko Anzai
- Junya Ikegaki
- Yuuichi Katou
- Kaori Kimura
- Ryou Kuchii
- Hajime Saitou
- Kazuya Shinoda
- Satoka Someya
- Hiroko Taguchi
- Kazuya Tashiro
- Masaya Tanaka
- Tatsuya Nemoto
- Ryou Wakabayashi
- Hitoshi Shinoto
- Kazuko Suzuki
- Izumi Izumida
- Katsuyuki Tanimoto
- Takahiro Shiraishi
- Junko Shiba
- Hiroaki Yano
- Miki Satake
- Aimi Nakui
- Yae Ebihara
- Tomomi Hasegawa
- Mami Kato
- Yuki Ogata
- Hiroyuki Fujikawa
- Nobuo Araki
- Yoshihiko Nakazato
- Takahiro Sasaki
- Tomokazu Shimadu
- Etsuko Imabayashi
- Asako Yasuda
- Etuko Yamamoto
- Natsumi Nakamata
- Noriko Miyauchi
- Keiko Ozawa
- Rieko Hashimoto
- Taishi Unezawa
- Takafumi Ichikawa
- Tunemichi Mihara
- Masaya Hirano
- Shinichi Watanabe
- Junichiro Fukuhara
- Hajime Matsudo
- Toshihiro Hayashi
- Toji Miyagawa
- Mizuho Yoshida
- Yuri Koide
- Eriko Samura
- Kurumi Fujii
- Nagae Orihara
- Akira Kunimatsu
- Takuya Arai
- Yoshiki Kojima
- Masami Goto
- Takeo Sarashina
- Syuichi Uzuki
- Seiji Katou
- Yoshiharu Sekine
- Yukihiro Takauchi
- Chiine Kagami
- Yasushi Nishina
- Maria Sakaibara
- Yumiko Okazaki
- Maki Obata
- Yuko Iwata
- Mizuho Minami
- Yasuko Hanabusa
- Hanae Shingyouji
- Kyoko Tottori
- Aya Tokumaru
- Makoto Ichinose
- Kazuya Kume
- Syunsuke Kahashi
- Kunimasa Arima
- Tadashi Tukamoto
- Yuko Nagahusa
- Maki Yamada
- Tiine Kodama
- Tomoko Takeuchi
- Keiichiro Ozawa
- Yoshiko Kawaji
- Kyouko Tottori
- Satoshi Sawada
- Makoto Mimatsu
- Daisuke Nakkamura
- Shunichirou Horiuchi
- Tsuneyoshi Ota
- Aiko Kodaka
- Yuko Tagata
- Tomoko Nakada
- Kiyoshi Sato
- Norio Murayama
- Satoshi Kimura
- Hirofumi Sakurai
- Takahiko Umahara
- Hidekazu Kanetaka
- Kaori Arashino
- Mikako Murakami
- Ai Kito
- Seiko Miyagi
- Kaori Doi
- Kazuyoshi Sasaki
- Akiko Ishiwata
- Yasushi Arai
- Akane Nogami
- Sumiko Fukuda
- Sayaka Kimura
- Ayako Machida
- Kuninori Kobayashi
- Mutsufusa Watanabe
- Hiromi Utashiro
- Yukiko Matsumoto
- Kumiko Hagiya
- Yoshiko Miyama
- Takako Shinozaki
- Haruko Hiraki
- Isamu Ohashi
- Akira Toriihara
- Shinichi Ohtani
- Toshifumi Matsui
- Tomomi Toyama
- Hideki Sakurai
- Kumiko Sugiura
- Hirofumi Taguchi
- Shizuo Hatashita
- Akari Imuta
- Akiko Matsudo
- Daichi Wakebe
- Hideki Hayakawa
- Mitsuhiro Ono
- Takayoshi Ohara
- Yutaka Arahata
- Akinori Takeda
- Akiko Yamaoka
- Hideyuki Hattori
- Miura Hisayuki
- Hidetoshi Endou
- Syousuke Satake
- Young Jae Hong
- Katsunari Iwai
- Kenji Yoshiyama
- Masaki Suenaga
- Sumiko Morita
- Teruhiko Kachi
- Rina Miura
- Takiko Kawai
- Ai Honda
- Kengo Itou
- Ken Fujiwara
- Rikio Katou
- Mariko Koyama
- Naohiko Fukaya
- Akira Tsuji
- Hitomi Shimizu
- Hiroyuki Fujisawa
- Takanori Sakata
- Kenjiro Ono
- Moeko Shinohara
- Yuki Soshi
- Kozue Niwa
- Chiaki Doumoto
- Mariko Hata
- Miyuki Matsushita
- Mai Tsukiyama
- Nozomi Takeda
- Sachiko Yonezawa
- Ichiro Matsunari
- Osamu Matsui
- Fumiaki Ueda
- Yasuji Ryu
- Masanobu Sakamoto
- Yasuomi Ouchi
- Madoka Chita
- Yumiko Fujita
- Rika Majima
- Hiromi Tsubota
- Umeo Shirasawa
- Masashi Sugimori
- Wataru Ariya
- Yuuzou Hagiwara
- Yasuo Tanizaki
- Hajime Takechi
- Chihiro Namiki
- Kengo Uemura
- Takeshi Kihara
- Shizuko Tanaka-Urayama
- Emiko Maeda
- Natsu Saito
- Shiho Satomi
- Konomi Kabata
- Tomohisa Okada
- Koichi Ishizu
- Shigeto Kawase
- Satoshi Fukumoto
- Masaki Kondo
- Yoko Oishi
- Mariko Yamazaki
- Yoku Asano
- Chizuru Hamaguchi
- Kei Yamada
- Kentaro Akazawa
- Shigenori Matsushima
- Takamasa Matsuo
- Toshiaki Nakagawa
- Takeshi Nii
- Takuji Nishida
- Kuniaki Kiuchi
- Masami Fukusumi
- Hideyuki Watanabe
- Akihiro Nogi
- Toshihisa Tanaka
- Naoyuki Sato
- Masayasu Okochi
- Takashi Morihara
- Shinji Tagami
- Noriyuki Hayashi
- Masahiko Takaya
- Tamiki Wada
- Mikiko Yokokoji
- Hiromichi Sugiyama
- Shuko Takeda
- Keiko Nomura
- Mutsumi Tomioka
- Eiichi Uchida
- Yoshiyuki Ikeda
- Mineto Murakami
- Takami Miki
- Suzuka Ataka
- Motokatsu Kanemoto
- Akitoshi Takeda
- Rie Azuma
- Yuki Iwamoto
- Naomi Tagawa
- Junko Masao
- Yuka Matsumoto
- Yuko Kikukawa
- Hisako Fujii
- Junko Matsumura
- Susumu Shiomi
- Joji Kawabe
- Yoshihiro Shimonishi
- Mitsuji Higashida
- Tomohiro Sahara
- Takashi Yamanaga
- Hiroyuki Tsushima
- Kazuo Sakai
- Haruhiko Oda
- Taichi Akisaki
- Mizuho Adachi
- Masako Kuranaga
- Sachi Takegawa
- Yoshihiko Tahara
- Takeshi Ishihara
- Hajime Honda
- Yuki Kishimoto
- Naoya Takeda
- Nao Imai
- Mayumi Yabe
- Kentaro Ida
- Daigo Anami
- Seiji Inoue
- Toshi Matsushita
- Reiko Wada
- Shinsuke Hiramatsu
- Hiromi Tonbara
- Reiko Yamamoto
- Kenji Wada-Isoe
- Saori Yamasaki
- Eijiro Yamashita
- Ichiro Ishikawa
- Sonoko Danjo
- Tomomi Shinohara
- Miyuki Ueno
- Yuka Kashimoto
- Yoshihiro Nishiyama
- Narihide Kimura
- Yasuhiro Sasakawa
- Takashi Ishimori
- Yukito Maeda
- Tatsuo Yamada
- Shinji Ouma
- Aika Fukuhara-Kaneumi
- Nami Sakamoto
- Rie Nagao
- Kengo Yoshimitsu
- Ryuji Nakamuta
- Minoru Tanaka
- Keiichirou Kaneda
- Yuusuke Yatabe
- Kazuki Honda
- Naoko Ichimi
- Fumi Akatuka
- Mariko Morinaga
- Miyako Noda
- Mika Kitajima
- Toshinori Hirai
- Shinya Shiraishi
- Naoji Amano
- Shinsuke Washizuka
- Shin Inuzuka
- Tetsuya Hagiwara
- Nobuhiro Sugiyama
- Yatsuka Okada
- Tomomi Ogihara
- Takehiko Yasaki
- Minori Kitayama
- Tomonori Owa
- Akiko Ryokawa
- Rie Takeuchi
- Satoe Goto
- Keiko Yamauchi
- Mie Ito
- Tomoki Kaneko
- Hitoshi Ueda
- Ban Mihara
- Hirofumi Kubo
- Akiko Takano
- Gou Yasui
- Masami Akuzawa
- Kaori Yamaguchi
- Toshinari Odawara
- Megumi Shimamura
- Mikiko Sugiyama
- Naomi Oota
- Shigeo Takebayashi
- Yoshigazu Hayakawa
- Mitsuhiro Idegawa
- Noriko Toya
- DOI
- https://doi.org/10.1136/bmjno-2022-000321
- Journal volume & issue
-
Vol. 4,
no. 2
Abstract
Background The AT(N) classification was proposed for categorising individuals according to biomarkers. However, AT(N) profiles may vary depending on the markers chosen and the target population.Methods We stratified 177 individuals who participated in the Japanese Alzheimer’s Disease Neuroimaging Initiative by AT(N) classification according to cerebrospinal fluid (CSF) biomarkers. We compared the frequency of AT(N) profiles between the classification using total tau and neurofilament light chain (NfL) as N markers (AT(N)tau and AT(N)NfL). Baseline characteristics, and longitudinal biological and clinical changes were examined between AT(N) profiles.Results We found that 9% of cognitively unimpaired subjects, 49% of subjects with mild cognitive impairment, and 61% of patients with Alzheimer’s disease (AD) dementia had the biological AD profile (ie, A+T+) in the cohort. The frequency of AT(N) profiles substantially differed between the AT(N)tau and AT(N)NfL classifications. When we used t-tau as the N marker (AT(N)tau), those who had T− were more frequently assigned to (N)−, whereas those who had T+were more frequently assigned to (N)+ than when we used NfL as the N marker (AT(N)NfL). During a follow-up, the AD continuum group progressed clinically and biologically compared with the normal biomarker group in both the AT(N)tau and AT(N)NfL classifications. More frequent conversion to dementia was observed in the non-AD pathological change group in the AT(N)tau classification, but not in the AT(N)NfL classification.Conclusions AT(N)tau and AT(N)NfL in CSF may capture different aspects of neurodegeneration and provide a different prognostic value. The AT(N) classification aids in understanding the AD continuum biology in various populations.
