Successful haploidentical stem cell transplantation with prophylactic administration of liposomal amphotericin B after invasive pulmonary zygomycosis

Testuro Ochi; Yuta Katayama; Takeshi Okatani; Ryota Imanaka; Kohei Kyo; Mitsuhiro Itagaki; Shinya Katsutani; Koji Iwato; Hideki Asaoku

Medical Mycology Case Reports (Dec 2017)

Successful haploidentical stem cell transplantation with prophylactic administration of liposomal amphotericin B after invasive pulmonary zygomycosis

Testuro Ochi,
Yuta Katayama,
Takeshi Okatani,
Ryota Imanaka,
Kohei Kyo,
Mitsuhiro Itagaki,
Shinya Katsutani,
Koji Iwato,
Hideki Asaoku

Affiliations

Testuro Ochi: Department of Hematology and Rheumatology, Tohoku University Hospital, 1-1, Seiryomachi, Aoba-ku Sendai-shi, Miyagi 980-0872, Japan; Corresponding author.
Yuta Katayama: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan
Takeshi Okatani: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan
Ryota Imanaka: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan
Kohei Kyo: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan
Mitsuhiro Itagaki: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan
Shinya Katsutani: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan
Koji Iwato: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan
Hideki Asaoku: Department of Hematology, Hiroshima Red Cross & Atomic-bomb Survivorsâ Hospital, 1-9-6, Sendamachi, Naka-ku Hiroshima-shi, Hiroshima 730-0052, Japan

Journal volume & issue: Vol. 18
pp. 1 – 4

Abstract

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A 54-year-old woman with acute myeloid leukemia (AML) achieved complete remission by induction chemotherapy, but developed zygomycosis after consolidation therapy. As zygomycosis could not be cured by liposomal amphotericin B and micafungin, left lower lobectomy was performed. As AML relapsed 7 months after onset, she received haploidentical stem cell transplantation under administration of liposomal amphotericin B. Despite experiencing severe acute graft-versus-host disease, she remains alive with no relapse of either zygomycosis or AML. Keywords: Zygomycosis, Acute myeloid leukemia, Liposomal amphotericin B, Stem cell transplantation

Published in Medical Mycology Case Reports

ISSN: 2211-7539 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/medical-mycology-case-reports/

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