Medicine Science (Dec 2018)

Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block

  • Ahmet Selim Ozkan,
  • Sedat Akbas,
  • Mehmet Akif Durak,
  • Mehmet Ali Erdogan,
  • Hakan Parlakpinar,
  • Nigar Vardi,
  • Onurhal Ozhan,
  • Ali Ozer

DOI
https://doi.org/10.5455/medscience.2018.07.8899
Journal volume & issue
Vol. 7, no. 4
pp. 891 – 7

Abstract

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Peripheral nerve blocks are commonly preferred worldwide for the purposes of anesthesia application and postoperative analgesia. In this study, we investigated the effects of phenytoin which has a similar mechanism to local anesthetics in terms of the duration of analgesia and quality. The study was performed on 32 Sprague-Dawley male rats. Rats were randomly grouped into 4 groups. Group S: Sham group (n: 8); 0,2 ml saline perineural unilateral sciatic nerve. Group L: Perineural levobupivacaine (0,2 ml 0,5% levobupivacaine, n: 8); Group Ph: Perineural phenytoin (0,2 ml 62,5 mg / kg, n: 8); Group L + PH: Perineural phenytoin and levobupivacaine (0,2 ml 0,5% levobupivacaine + 62,5 mg / kg phenytoin, n: 8). Hot-plate and tail- flick tests were performed to measure acute thermal pain and histological changes were evaluated. The latency time at 30 minute in Group L+Ph were significantly increased when compared to the other groups during evaluation of the hot plate test. There was a significant difference in terms of latency time at 30 minute in Group L+Ph in the Tail Flick test and the latency time in Group L+Ph was longer when compared to the other groups (p [Med-Science 2018; 7(4.000): 891-7]

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