Nature Communications (Sep 2017)
A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
- Chao Shan,
- Antonio E. Muruato,
- Brett W. Jagger,
- Justin Richner,
- Bruno T. D. Nunes,
- Daniele B. A. Medeiros,
- Xuping Xie,
- Jannyce G. C. Nunes,
- Kaitlyn M. Morabito,
- Wing-Pui Kong,
- Theodore C. Pierson,
- Alan D. Barrett,
- Scott C. Weaver,
- Shannan L. Rossi,
- Pedro F. C. Vasconcelos,
- Barney S. Graham,
- Michael S. Diamond,
- Pei-Yong Shi
Affiliations
- Chao Shan
- Department of Biochemistry & Molecular Biology, University of Texas Medical Branch
- Antonio E. Muruato
- Department of Microbiology & Immunology, University of Texas Medical Branch
- Brett W. Jagger
- Department of Medicine, Washington University School of Medicine
- Justin Richner
- Department of Medicine, Washington University School of Medicine
- Bruno T. D. Nunes
- Department of Biochemistry & Molecular Biology, University of Texas Medical Branch
- Daniele B. A. Medeiros
- Department of Biochemistry & Molecular Biology, University of Texas Medical Branch
- Xuping Xie
- Department of Biochemistry & Molecular Biology, University of Texas Medical Branch
- Jannyce G. C. Nunes
- Department of Biochemistry & Molecular Biology, University of Texas Medical Branch
- Kaitlyn M. Morabito
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Wing-Pui Kong
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Theodore C. Pierson
- Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health
- Alan D. Barrett
- Institute for Human Infections & Immunity, University of Texas Medical Branch
- Scott C. Weaver
- Department of Microbiology & Immunology, University of Texas Medical Branch
- Shannan L. Rossi
- Institute for Human Infections & Immunity, University of Texas Medical Branch
- Pedro F. C. Vasconcelos
- Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health
- Barney S. Graham
- Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health
- Michael S. Diamond
- Department of Medicine, Washington University School of Medicine
- Pei-Yong Shi
- Department of Biochemistry & Molecular Biology, University of Texas Medical Branch
- DOI
- https://doi.org/10.1038/s41467-017-00737-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models.
