Communications Biology (Aug 2022)
Human alveolar progenitors generate dual lineage bronchioalveolar organoids
- Karen Hoffmann,
- Benedikt Obermayer,
- Katja Hönzke,
- Diana Fatykhova,
- Zeynep Demir,
- Anna Löwa,
- Luiz Gustavo Teixeira Alves,
- Emanuel Wyler,
- Elena Lopez-Rodriguez,
- Maren Mieth,
- Morris Baumgardt,
- Judith Hoppe,
- Theresa C. Firsching,
- Mario Tönnies,
- Torsten T. Bauer,
- Stephan Eggeling,
- Hong-Linh Tran,
- Paul Schneider,
- Jens Neudecker,
- Jens C. Rückert,
- Achim D. Gruber,
- Matthias Ochs,
- Markus Landthaler,
- Dieter Beule,
- Norbert Suttorp,
- Stefan Hippenstiel,
- Andreas C. Hocke,
- Mirjana Kessler
Affiliations
- Karen Hoffmann
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Benedikt Obermayer
- Core Unit Bioinformatics, Berlin Institute of Health (BIH), Charite-Universitätsmedizin
- Katja Hönzke
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Diana Fatykhova
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Zeynep Demir
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Anna Löwa
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Luiz Gustavo Teixeira Alves
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
- Emanuel Wyler
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
- Elena Lopez-Rodriguez
- Institute of Functional Anatomy, Charité-Universitätsmedizin Berlin
- Maren Mieth
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Morris Baumgardt
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Judith Hoppe
- Institute of Veterinary Pathology, Freie Universität Berlin
- Theresa C. Firsching
- Institute of Veterinary Pathology, Freie Universität Berlin
- Mario Tönnies
- HELIOS Clinic Emil von Behring, Department of Pneumology and Department of Thoracic Surgery, Chest Hospital Heckeshorn
- Torsten T. Bauer
- HELIOS Clinic Emil von Behring, Department of Pneumology and Department of Thoracic Surgery, Chest Hospital Heckeshorn
- Stephan Eggeling
- Department of Thoracic Surgery, Vivantes Clinics Neukölln
- Hong-Linh Tran
- Department of Thoracic Surgery, Vivantes Clinics Neukölln
- Paul Schneider
- Department for General and Thoracic Surgery, DRK Clinics
- Jens Neudecker
- Department of General, Visceral, Vascular and Thoracic Surgery, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Jens C. Rückert
- Department of General, Visceral, Vascular and Thoracic Surgery, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Achim D. Gruber
- Institute of Veterinary Pathology, Freie Universität Berlin
- Matthias Ochs
- Institute of Functional Anatomy, Charité-Universitätsmedizin Berlin
- Markus Landthaler
- Berlin Institute for Medical Systems Biology (BIMSB), Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
- Dieter Beule
- Core Unit Bioinformatics, Berlin Institute of Health (BIH), Charite-Universitätsmedizin
- Norbert Suttorp
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Stefan Hippenstiel
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Andreas C. Hocke
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Mirjana Kessler
- Department of Infectious Diseases and Respiratory Medicine, Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- DOI
- https://doi.org/10.1038/s42003-022-03828-5
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
The GSK3 inhibitor CHIR99021 is required to maintain the alveolar lineage in alveolar progenitors grown in airway media or AT2 cells become plastic, with the observed effects acting outside of its role as a GSK3B inhibitor.
