NIHR Open Research (May 2024)
An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 2; peer review: 2 approved]
- David Clark,
- Tommi Kalevi Korhonen,
- Sara Venturini,
- Sujit Gnanakumar,
- Thomas Bashford,
- Midhun Mohan,
- Indira Devi Bhagavatula,
- Ronnie Baticulon,
- Rocío Fernández-Méndez,
- Ignatius Esene,
- Deepak Gupta,
- Anthony Figaji,
- Tsegazeab Laeke,
- Tariq Khan,
- David Menon,
- Michael Martin,
- Kee B. Park,
- Wellingson Paiva,
- Andres M. Rubiano,
- Jogi V. Pattisapu,
- Hamisi Shabani,
- Vijaya Sekhar,
- Davi Solla,
- Kachinga Sichizya,
- Manjul Tripathi,
- Abenezer Tirsit,
- Bart Depreitere,
- Carole Turner,
- Laura Lippa,
- Corrado Iaccarino,
- Gail Rosseau,
- Andrew Reisner,
- Rikin Trivedi,
- Franco Servadei,
- Angelos Kolias,
- Vicknes Waran,
- Peter Hutchinson,
- Alexis Joannides
Affiliations
- David Clark
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Tommi Kalevi Korhonen
- ORCiD
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Sara Venturini
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Sujit Gnanakumar
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Thomas Bashford
- ORCiD
- Health Systems Design Group, Department of Engineering, University of Cambridge, Cambridge, UK
- Midhun Mohan
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Indira Devi Bhagavatula
- ORCiD
- Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, NIMHANS, Bengaluru, Karnataka, India
- Ronnie Baticulon
- Division of Neurosurgery, Department of Neurosciences, Philippine General Hospital & University of the Philippines Manila, Manila, Philippines
- Rocío Fernández-Méndez
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Ignatius Esene
- Division of Neurosurgery, Faculty of Health Sciences, The University of Bamenda, Bambili, Cameroon
- Deepak Gupta
- Department of neurosurgery, All India Institute of Medical Sciences, New Delhi, India
- Anthony Figaji
- Division of Neurosurgery and Neurosciences Institute, University of Cape Town, Cape Town, South Africa
- Tsegazeab Laeke
- Division of Neurosurgery, Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
- Tariq Khan
- Department of Neurosurgery, North Western General and Research Hospital, Peshawar, Pakistan
- David Menon
- Division of Anaesthesia, Department of Medicine, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
- Michael Martin
- ORCiD
- Orion MedTech Ltd. CIC, Cambridge, UK
- Kee B. Park
- Global Neurosurgery Initiative-Program in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA
- Wellingson Paiva
- Division of Neurosurgery, Department of Neurology, School of Medicine, University of Sao Paulo, São Paulo, Brazil
- Andres M. Rubiano
- Neurosciences Institute, El Bosque University, Bogotá, Colombia
- Jogi V. Pattisapu
- University of Central Florida College of Medicine, Orlando, Florida, USA
- Hamisi Shabani
- ORCiD
- Department of Neurosurgery, Muhimbili Orthopaedic Institute, Dar es Salaam, Tanzania
- Vijaya Sekhar
- Department of Neurosurgery, King George Hospital, Visakhapatnam, Andra Pradesh, India
- Davi Solla
- Division of Neurosurgery, Department of Neurology, School of Medicine, University of Sao Paulo, São Paulo, Brazil
- Kachinga Sichizya
- Department of Neurosurgery, University Teaching Hospital, Lusaka, Zambia
- Manjul Tripathi
- Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India
- Abenezer Tirsit
- Division of Neurosurgery, Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
- Bart Depreitere
- Department of Neurosciences, University Hospital Leuven, UZ, Leuven, Belgium
- Carole Turner
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Laura Lippa
- ORCiD
- Department of Neurosurgery, Ospedale Niguarda, Milan, Italy
- Corrado Iaccarino
- School of Neurosurgery, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
- Gail Rosseau
- Barrow Global, Barrow Neurosurgical Institute, Phoenix, Arizona, USA
- Andrew Reisner
- ORCiD
- Departments of Neurosurgery and Pediatrics, Children's Healthcare of Atlanta & Emory University School of Medicine, Atlanta, Georgia, USA
- Rikin Trivedi
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Franco Servadei
- Department of Neurosurgery, Humanitas Research Hospital-IRCCS & Humanitas University, Rozzano, Milan, Italy
- Angelos Kolias
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Vicknes Waran
- Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
- Peter Hutchinson
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Alexis Joannides
- NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UK
- Journal volume & issue
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Vol. 3
Abstract
Background The epidemiology of traumatic brain injury (TBI) is unclear – it is estimated to affect 27–69 million individuals yearly with the bulk of the TBI burden in low-to-middle income countries (LMICs). Research has highlighted significant between-hospital variability in TBI outcomes following emergency surgery, but the overall incidence and epidemiology of TBI remains unclear. To address this need, we established the Global Epidemiology and Outcomes following Traumatic Brain Injury (GEO-TBI) registry, enabling recording of all TBI cases requiring admission irrespective of surgical treatment. Objective The GEO-TBI: Incidence study aims to describe TBI epidemiology and outcomes according to development indices, and to highlight best practices to facilitate further comparative research. Design Multi-centre, international, registry-based, prospective cohort study. Subjects Any unit managing TBI and participating in the GEO-TBI registry will be eligible to join the study. Each unit will select a 90-day study period. All TBI patients meeting the registry inclusion criteria (neurosurgical/ICU admission or neurosurgical operation) during the selected study period will be included in the GEO-TBI: Incidence. Methods All units will form a study team, that will gain local approval, identify eligible patients and input data. Data will be collected via the secure registry platform and validated after collection. Identifiers may be collected if required for local utility in accordance with the GEO-TBI protocol. Data Data related to initial presentation, interventions and short-term outcomes will be collected in line with the GEO-TBI core dataset, developed following consensus from an iterative survey and feedback process. Patient demographics, injury details, timing and nature of interventions and post-injury care will be collected alongside associated complications. The primary outcome measures for the study will be the Glasgow Outcome at Discharge Scale (GODS) and 14-day mortality. Secondary outcome measures will be mortality and extended Glasgow Outcome Scale (GOSE) at the most recent follow-up timepoint.
