Direct oral anticoagulants. The story of success

Abstract

Lets organize a nice funeral for warfarin – told by Eugene Braunwald twenty years ago, when first large scale studies had been planned and started with direct oral anticoagulants (DOACs), earlier called novel oral anticoagulants (NOACS). However this funeral has not happened yet, the paradigm shift, the success, the safety, the accessibilty and the comfort of oral anticoagulant treatment has become part of our praxis. These medicines are currently accessible as generics, improving the general usage of them. Why we could not undertake coumadins, why these drugs still remained part of our medical activities – will be shown next.

Keywords

• oral anticoagulants
• atrial fibrillation
• venous thromboembolism
• artificial heart valve