Abnormal microRNA expression in the course of hematological malignancies

Abstract

Agnieszka Szymczyk,1 Arkadiusz Macheta,2 Monika Podhorecka2 1Independent Clinical Transplantology Unit, Medical University of Lublin, Lublin, Poland; 2Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland Abstract: Research on the carcinogenesis process is currently focused primarily on understanding its genetic basis and molecular abnormalities that may be predictive factors and therapeutic targets. It was clearly confirmed recently that microRNAs are involved in the mechanisms of leukocyte development, differentiation, and apoptosis, as well as in the pathogenesis of proliferative diseases of the hematopoietic system. Currently, research strategies allow determination of the deregulation of microRNA profiles in relation to other cytogenetic aberrations, as well as prognostic factors and primary end points. The problem of the possibility of their use as therapeutic targets is also increasingly discussed. In this article, we analyze literature data on abnormalities in microRNA expression in proliferative diseases of the hematopoietic system in the context of classic cytogenetic and molecular aberrations. Keywords: hematological malignancies, microRNA, cytogenetic abnormalities

Keywords

• haematological malignancies
• microRNA
• cytogenetic abnormalities