Iranian Journal of Chemistry & Chemical Engineering (Dec 1998)

Stannous Chloride: A Reagent for Removal of Dimethoxytrityl Group from 5'-Dimethoxytrityl Nucleosides

  • Ali Khalafi Nezhad,
  • Reza Fareghi Alamdari

Journal volume & issue
Vol. 17, no. 2
pp. 58 – 60

Abstract

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Detritylation of 5'-dimethoxytrityl nucleosides have been quantitatively achieved in minutes at room temperature under aprotic neutral conditions by using stannous chloride. Of additional practical consideration and in contrast to protic acids, no depurination was observed with this reagent.

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