Maternal Diet Associated with Oligosaccharide Abundances in Human Milk from Latina Mothers

Pari Mokhtari; Kelsey A. Schmidt; Hashem Zamanian; Mahsa Babaei; Christopher J. Machle; Diana Trifonova; Tanya L. Alderete; Elizabeth A. Holzhausen; Jonatan Ottino-González; Bridget N. Chalifour; Roshonda B. Jones; Annalee Furst; Chloe Yonemitsu; Lars Bode; Michael I. Goran

doi:10.3390/nu16121795

Nutrients (Jun 2024)

Maternal Diet Associated with Oligosaccharide Abundances in Human Milk from Latina Mothers

Pari Mokhtari,
Kelsey A. Schmidt,
Hashem Zamanian,
Mahsa Babaei,
Christopher J. Machle,
Diana Trifonova,
Tanya L. Alderete,
Elizabeth A. Holzhausen,
Jonatan Ottino-González,
Bridget N. Chalifour,
Roshonda B. Jones,
Annalee Furst,
Chloe Yonemitsu,
Lars Bode,
Michael I. Goran

Affiliations

Pari Mokhtari: Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
Kelsey A. Schmidt: Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
Hashem Zamanian: The Saban Research Institute (TSRI) Data Science, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
Mahsa Babaei: Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
Christopher J. Machle: Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
Diana Trifonova: Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
Tanya L. Alderete: Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Elizabeth A. Holzhausen: Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
Jonatan Ottino-González: Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
Bridget N. Chalifour: Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
Roshonda B. Jones: Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Annalee Furst: Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA 92123, USA
Chloe Yonemitsu: Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA 92123, USA
Lars Bode: Department of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA 92123, USA
Michael I. Goran: Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA

DOI: https://doi.org/10.3390/nu16121795
Journal volume & issue: Vol. 16, no. 12
p. 1795

Abstract

Read online

Growing evidence indicates that human milk oligosaccharides (HMOs) are important bioactive compounds that enhance health and developmental outcomes in breastfed babies. Maternal dietary intake likely contributes to variation in HMO composition, but studies identifying diet–HMO relationships are few and inconsistent. This study aimed to investigate how the maternal intake of macronutrients and micronutrients—specifically proteins, fats, vitamins, and minerals—associated with HMOs at 1 month (n = 210), 6 months (n = 131), and 12 months postpartum (n = 84). Several associations between maternal dietary factors and HMO profiles were identified utilizing partial correlation analysis. For example, maternal free sugar (rho = −0.02, p p p All p = 0.03). Overall, the results provide additional evidence supporting a role for maternal nutrition in shaping HMO profiles, which may inform future intervention strategies with the potential of improving infant growth and development through optimal HMO levels in mothers’ milk.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

About the journal

Abstract

Keywords