Synthesised Conductive/Magnetic Composite Particles for Magnetic Ablations of Tumours
Chiang-Wen Lee,
Ju-Fang Liu,
Wen-Chun Wei,
Ming-Hsien Chiang,
Ting-Yuan Chen,
Shu-Hsien Liao,
Yao-Chang Chiang,
Wen-Cheng Kuo,
Kuen-Lin Chen,
Kuo-Ti Peng,
Yen-Bin Liu,
Jen-Jie Chieh
Affiliations
Chiang-Wen Lee
Department of Nursing, Division of Basic Medical Sciences, Chronic Diseases and Health Promotion Research Center and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Puzi City 61363, Taiwan
Ju-Fang Liu
School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan
Wen-Chun Wei
Institute of Electro-Optical Engineering, Gongguan Campus, National Taiwan Normal University, Taipei 106, Taiwan
Ming-Hsien Chiang
Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 106, Taiwan
Ting-Yuan Chen
Institute of Electro-Optical Engineering, Gongguan Campus, National Taiwan Normal University, Taipei 106, Taiwan
Shu-Hsien Liao
Institute of Electro-Optical Engineering, Gongguan Campus, National Taiwan Normal University, Taipei 106, Taiwan
Yao-Chang Chiang
Department of Nursing, Division of Basic Medical Sciences, Chronic Diseases and Health Promotion Research Center and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Puzi City 61363, Taiwan
Wen-Cheng Kuo
Department of Mechanical and Automation Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan
Kuen-Lin Chen
Department of Physics, National Chung Hsing University, Taichung 402202, Taiwan
Kuo-Ti Peng
Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi City 61363, Taiwan
Yen-Bin Liu
Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100229, Taiwan
Jen-Jie Chieh
Institute of Electro-Optical Engineering, Gongguan Campus, National Taiwan Normal University, Taipei 106, Taiwan
Ablation is a clinical cancer treatment, but some demands are still unsatisfied, such as electromagnetic interferences amongst multiple ablation needles during large tumour treatments. This work proposes a physical synthesis for composite particles of biocompatible iron oxide particles and liquid metal gallium (Ga) with different alternative-current (AC)-magnetic-field-induced heat mechanisms of magnetic particle hyperthermia and superior resistance heat. By some imaging, X-ray diffraction, and vibrating sample magnetometer, utilised composite particles were clearly identified as the cluster of few iron oxides using the small weight ratio of high-viscosity liquid metal Ga as conjugation materials without surfactants for physical targeting of limited fluidity. Hence, well penetration inside the tissue and the promotion rate of heat generation to fit the ablation requirement of at least 60 °C in a few seconds are achieved. For the injection and the post-injection magnetic ablations, the volume variation ratios of mice dorsal tumours on Day 12 were expressed at around one without tumour growth. Its future powerful potentiality is expected through a percutaneous injection.
