Nature Communications (Aug 2019)

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

  • Marcel A. Dammert,
  • Johannes Brägelmann,
  • Rachelle R. Olsen,
  • Stefanie Böhm,
  • Niloufar Monhasery,
  • Christopher P. Whitney,
  • Milind D. Chalishazar,
  • Hannah L. Tumbrink,
  • Matthew R. Guthrie,
  • Sebastian Klein,
  • Abbie S. Ireland,
  • Jeremy Ryan,
  • Anna Schmitt,
  • Annika Marx,
  • Luka Ozretić,
  • Roberta Castiglione,
  • Carina Lorenz,
  • Ron D. Jachimowicz,
  • Elmar Wolf,
  • Roman K. Thomas,
  • John T. Poirier,
  • Reinhard Büttner,
  • Triparna Sen,
  • Lauren A. Byers,
  • H. Christian Reinhardt,
  • Anthony Letai,
  • Trudy G. Oliver,
  • Martin L. Sos

DOI
https://doi.org/10.1038/s41467-019-11371-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

The expression of oncogenic MYC paralogs in small cell lung cancer is mutually exclusive. In this study, the authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating these cancers.