Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2

• Miao Zheng,
• Bo Feng,
• Yumin Zhang,
• Xin Liu,
• Na Zhao,
• Hui Liu,
• Zichao Xu,
• Xinheng He,
• Zhiyan Qu,
• Shizhao Chen,
• Zhidong Jiang,
• Xi Cheng,
• Hong Liu,
• Yi Zang,
• Linxiang Zhao,
• Jie Zheng,
• Leike Zhang,
• Jia Li,
• Yu Zhou

Affiliations

Miao Zheng

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Bo Feng

School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang 110016, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Yumin Zhang

State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China

Xin Liu

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Na Zhao

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Hui Liu

State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Zichao Xu

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Xinheng He

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Zhiyan Qu

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Shizhao Chen

State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Zhidong Jiang

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China; Lingang Laboratory, Shanghai 200031, China

Xi Cheng

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Hong Liu

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China

Yi Zang

Lingang Laboratory, Shanghai 200031, China

Linxiang Zhao

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding authors.

Jie Zheng

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authors.

Leike Zhang

State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China; Corresponding authors.

Jia Li

School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang 110016, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China; Corresponding authors.

Yu Zhou

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China; Corresponding authors.