Nature Communications (Jan 2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
- Jodie P. Goodridge,
- Benedikt Jacobs,
- Michelle L. Saetersmoen,
- Dennis Clement,
- Quirin Hammer,
- Trevor Clancy,
- Ellen Skarpen,
- Andreas Brech,
- Johannes Landskron,
- Christian Grimm,
- Aline Pfefferle,
- Leonardo Meza-Zepeda,
- Susanne Lorenz,
- Merete Thune Wiiger,
- William E. Louch,
- Eivind Heggernes Ask,
- Lisa L. Liu,
- Vincent Yi Sheng Oei,
- Una Kjällquist,
- Sten Linnarsson,
- Sandip Patel,
- Kjetil Taskén,
- Harald Stenmark,
- Karl-Johan Malmberg
Affiliations
- Jodie P. Goodridge
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Benedikt Jacobs
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Michelle L. Saetersmoen
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Dennis Clement
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Quirin Hammer
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet
- Trevor Clancy
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Ellen Skarpen
- Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital
- Andreas Brech
- Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital
- Johannes Landskron
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Christian Grimm
- Department of Pharmacology and Toxicology, Faculty of Medicine, University of Munich (LMU)
- Aline Pfefferle
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet
- Leonardo Meza-Zepeda
- Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital
- Susanne Lorenz
- Genomics Core Facility, Department of Core Facilities, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital
- Merete Thune Wiiger
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- William E. Louch
- Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo
- Eivind Heggernes Ask
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Lisa L. Liu
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet
- Vincent Yi Sheng Oei
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Una Kjällquist
- Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Sten Linnarsson
- Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Sandip Patel
- Department of Cell and Developmental Biology, University College London
- Kjetil Taskén
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- Harald Stenmark
- Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital
- Karl-Johan Malmberg
- The KG Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo
- DOI
- https://doi.org/10.1038/s41467-019-08384-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Natural killer (NK) cells are functionally calibrated against self MHC during a process termed education. Here the authors show that NK cell education is associated with the accumulation of dense-core secretory lysosomes for expedited release of granzyme B and Ca2+ flux upon target recognition and NK cell activation.
