The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer

Hossein Maghsoudi; Farhad Sheikhnia; Przemysław Sitarek; Nooshin Hajmalek; Sepideh Hassani; Vahid Rashidi; Sadaf Khodagholi; Seyed Mostafa Mir; Faezeh Malekinejad; Fatemeh Kheradmand; Mansour Ghorbanpour; Navid Ghasemzadeh; Tomasz Kowalczyk

doi:10.3390/cancers15225435

Cancers (Nov 2023)

The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer

Hossein Maghsoudi,
Farhad Sheikhnia,
Przemysław Sitarek,
Nooshin Hajmalek,
Sepideh Hassani,
Vahid Rashidi,
Sadaf Khodagholi,
Seyed Mostafa Mir,
Faezeh Malekinejad,
Fatemeh Kheradmand,
Mansour Ghorbanpour,
Navid Ghasemzadeh,
Tomasz Kowalczyk

Affiliations

Hossein Maghsoudi: Student Research Committee, Urmia University of Medical Sciences, Urmia 57147-83734, Iran
Farhad Sheikhnia: Student Research Committee, Urmia University of Medical Sciences, Urmia 57147-83734, Iran
Przemysław Sitarek: Department of Medical Biology, Medical University of Lodz, 90-151 Lodz, Poland
Nooshin Hajmalek: Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol 47176-47754, Iran
Sepideh Hassani: Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia 57147-83734, Iran
Vahid Rashidi: Student Research Committee, Urmia University of Medical Sciences, Urmia 57147-83734, Iran
Sadaf Khodagholi: School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada
Seyed Mostafa Mir: Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 49189-36316, Iran
Faezeh Malekinejad: Student Research Committee, Urmia University of Medical Sciences, Urmia 57147-83734, Iran
Fatemeh Kheradmand: Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia 57147-83734, Iran
Mansour Ghorbanpour: Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-88349, Iran
Navid Ghasemzadeh: Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia 57147-83734, Iran
Tomasz Kowalczyk: Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland

DOI: https://doi.org/10.3390/cancers15225435
Journal volume & issue: Vol. 15, no. 22
p. 5435

Abstract

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Prostate cancer (PC) is the second most common type of cancer and the leading cause of death among men worldwide. Preventing the progression of cancer after treatments such as radical prostatectomy, radiation therapy, and hormone therapy is a major concern faced by prostate cancer patients. Inflammation, which can be caused by various factors such as infections, the microbiome, obesity and a high-fat diet, is considered to be the main cause of PC. Inflammatory cells are believed to play a crucial role in tumor progression. Therefore, nonsteroidal anti-inflammatory drugs along with their effects on the treatment of inflammation-related diseases, can prevent cancer and its progression by suppressing various inflammatory pathways. Recent evidence shows that nonsteroidal anti-inflammatory drugs are effective in the prevention and treatment of prostate cancer. In this review, we discuss the different pathways through which these drugs exert their potential preventive and therapeutic effects on prostate cancer.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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