Results in Chemistry (Jan 2023)
From optically pure pyridinium salts to some new dihydro-2H-oxazolo[3,2-a]pyridines
Abstract
Treatment of 2,4,6-triphenylpiridinium salts, bearing a chiral β-hydroxy alkyl N-substituent with diluted aqueous sodium hydroxide afforded four new dihydrooxazolo[3,2a]pyridines,as an almost equimolar mixture of diastereomers. However, a highly selective ring closure reaction was observed for the pyridium salt derived from (1S,2S)-(+)-2-amino-1-phenyl-1,3-propanediol.
