Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development

Kiara Freitag; Pascale Eede; Andranik Ivanov; Nele Sterczyk; Shirin Schneeberger; Tatiana Borodina; Sascha Sauer; Dieter Beule; Frank L. Heppner

doi:10.1038/s42003-023-04410-3

Communications Biology (Jan 2023)

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development

Kiara Freitag,
Pascale Eede,
Andranik Ivanov,
Nele Sterczyk,
Shirin Schneeberger,
Tatiana Borodina,
Sascha Sauer,
Dieter Beule,
Frank L. Heppner

Affiliations

Kiara Freitag: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology
Pascale Eede: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology
Andranik Ivanov: Core Unit Bioinformatics, Berlin Institute of Health, Charité - University Hospital Berlin
Nele Sterczyk: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology
Shirin Schneeberger: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology
Tatiana Borodina: Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, Berlin, Germany and Berlin Institute of Health (BIH)
Sascha Sauer: Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, Berlin, Germany and Berlin Institute of Health (BIH)
Dieter Beule: Core Unit Bioinformatics, Berlin Institute of Health, Charité - University Hospital Berlin
Frank L. Heppner: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology

DOI: https://doi.org/10.1038/s42003-023-04410-3
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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Functional and transcriptomic comparison of primary neonatal, adult and ESC-derived astrocytes reveals major variations, highlighting the importance for an informed choice of astrocyte origin for research questions.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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