Nature Communications (Jan 2019)
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function
- J. A. Hurcombe,
- P. Hartley,
- A. C. Lay,
- L. Ni,
- J. J. Bedford,
- J. P. Leader,
- S. Singh,
- A. Murphy,
- C. L. Scudamore,
- E. Marquez,
- A. F. Barrington,
- V. Pinto,
- M. Marchetti,
- L.-F. Wong,
- J. Uney,
- M. A. Saleem,
- P. W. Mathieson,
- S. Patel,
- R. J. Walker,
- J. R. Woodgett,
- S. E. Quaggin,
- G. I. Welsh,
- R. J. M. Coward
Affiliations
- J. A. Hurcombe
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- P. Hartley
- Bournemouth University
- A. C. Lay
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- L. Ni
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- J. J. Bedford
- Dunedin School of Medicine, University of Otago
- J. P. Leader
- Dunedin School of Medicine, University of Otago
- S. Singh
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- A. Murphy
- Department of Pathology, Southern General Hospital
- C. L. Scudamore
- Mary Lyon Centre, MRC Harwell, Didcot
- E. Marquez
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- A. F. Barrington
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- V. Pinto
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- M. Marchetti
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- L.-F. Wong
- Translational Health Sciences, University of Bristol
- J. Uney
- Translational Health Sciences, University of Bristol
- M. A. Saleem
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- P. W. Mathieson
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- S. Patel
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System & University of Toronto
- R. J. Walker
- Dunedin School of Medicine, University of Otago
- J. R. Woodgett
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System & University of Toronto
- S. E. Quaggin
- Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine
- G. I. Welsh
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- R. J. M. Coward
- Bristol Renal, Dorothy Hodgkin Building, University of Bristol
- DOI
- https://doi.org/10.1038/s41467-018-08235-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of function both during development and in maturity.
