Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models

D. Betty Lew; Christie F. Michael; Tracie Overbeck; W. Scout Robinson; Erin L. Rohman; Jeffrey M. Lehman; Jennifer K. Patel; Brandi Eiseman; Kim S. LeMessurier; Amali E. Samarasinghe; M. Waleed Gaber

doi:10.1155/2017/3432701

Journal of Immunology Research (Jan 2017)

Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models

D. Betty Lew,
Christie F. Michael,
Tracie Overbeck,
W. Scout Robinson,
Erin L. Rohman,
Jeffrey M. Lehman,
Jennifer K. Patel,
Brandi Eiseman,
Kim S. LeMessurier,
Amali E. Samarasinghe,
M. Waleed Gaber

Affiliations

D. Betty Lew: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Christie F. Michael: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Tracie Overbeck: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
W. Scout Robinson: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Erin L. Rohman: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Jeffrey M. Lehman: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Jennifer K. Patel: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Brandi Eiseman: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Kim S. LeMessurier: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
Amali E. Samarasinghe: Department of Pediatrics, University of Tennessee Health Science Center (UTHSC) and Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN, USA
M. Waleed Gaber: Department of Pediatrics and Hematology-Oncology, Baylor College of Medicine and Texas Children’s Cancer Center, Houston, TX, USA

DOI: https://doi.org/10.1155/2017/3432701
Journal volume & issue: Vol. 2017

Abstract

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One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment. This proof-of-concept study would facilitate future development of a potential asthma therapeutic agent with dual function of anti-inflammatory and anti-smooth muscle remodeling effects.

Published in Journal of Immunology Research

ISSN: 2314-8861 (Print); 2314-7156 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.hindawi.com/journals/jir/

About the journal