Communications Biology (Jul 2021)

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

  • Alyssa Vito,
  • Omar Salem,
  • Nader El-Sayes,
  • Ian P. MacFawn,
  • Ana L. Portillo,
  • Katy Milne,
  • Danielle Harrington,
  • Ali A. Ashkar,
  • Yonghong Wan,
  • Samuel T. Workenhe,
  • Brad H. Nelson,
  • Tullia C. Bruno,
  • Karen L. Mossman

DOI
https://doi.org/10.1038/s42003-021-02375-9
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 19

Abstract

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Vito et al. investigated the effects of combination therapy in a TNBC tumor model and reported increased tumor-infiltrating lymphocytes that contributed to an improved response to immune checkpoint blockade. By depletion of circulating B cells prior to therapy, the authors showed a loss of therapeutic efficacy and simultaneous expansion of myeloid-derived suppressor cells.