Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

Sumedha Agashe; Chinnu Rose Joseph; Teresa Anne Clarisse Reyes; Demis Menolfi; Michele Giannattasio; Anja Waizenegger; Barnabas Szakal; Dana Branzei

doi:10.1038/s41467-021-22217-w

Nature Communications (Apr 2021)

Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

Sumedha Agashe,
Chinnu Rose Joseph,
Teresa Anne Clarisse Reyes,
Demis Menolfi,
Michele Giannattasio,
Anja Waizenegger,
Barnabas Szakal,
Dana Branzei

Affiliations

Sumedha Agashe: IFOM, the FIRC Institute of Molecular Oncology
Chinnu Rose Joseph: IFOM, the FIRC Institute of Molecular Oncology
Teresa Anne Clarisse Reyes: IFOM, the FIRC Institute of Molecular Oncology
Demis Menolfi: IFOM, the FIRC Institute of Molecular Oncology
Michele Giannattasio: IFOM, the FIRC Institute of Molecular Oncology
Anja Waizenegger: IFOM, the FIRC Institute of Molecular Oncology
Barnabas Szakal: IFOM, the FIRC Institute of Molecular Oncology
Dana Branzei: IFOM, the FIRC Institute of Molecular Oncology

DOI: https://doi.org/10.1038/s41467-021-22217-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Smc5/6, part of the structural maintenance of chromosomes (SMC) family, plays roles in genome structural integrity. Here the authors reveal that Smc5/6 acts jointly with Top3 within the STR complex to mediate DNA replication completion at genomic natural pausing sites (NPSs).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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