NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

Francisco Freixo; Paula Martinez Delgado; Yasmina Manso; Carlos Sánchez-Huertas; Cristina Lacasa; Eduardo Soriano; Joan Roig; Jens Lüders

doi:10.1038/s41467-018-04706-7

Nature Communications (Jun 2018)

NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization

Francisco Freixo,
Paula Martinez Delgado,
Yasmina Manso,
Carlos Sánchez-Huertas,
Cristina Lacasa,
Eduardo Soriano,
Joan Roig,
Jens Lüders

Affiliations

Francisco Freixo: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Paula Martinez Delgado: Molecular Biology Institute of Barcelona (IBMB-CSIC)
Yasmina Manso: Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Institute of Neurosciences, University of Barcelona
Carlos Sánchez-Huertas: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Cristina Lacasa: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Eduardo Soriano: Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Institute of Neurosciences, University of Barcelona
Joan Roig: Molecular Biology Institute of Barcelona (IBMB-CSIC)
Jens Lüders: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-018-04706-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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NEK7 is a kinase known for its role in mitotic spindle assembly, driving centrosome separation in prophase through regulation of the kinesin Eg5. Here, the authors show that NEK7 and Eg5 also control dendrite morphogenesis in postmitotic neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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