Effects of Aronia melanocarpa Constituents on Biofilm Formation of Escherichia coli and Bacillus cereus
Marie Bräunlich,
Ole A. Økstad,
Rune Slimestad,
Helle Wangensteen,
Karl E. Malterud,
Hilde Barsett
Affiliations
Marie Bräunlich
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, Oslo N-0316, Norway
Ole A. Økstad
Laboratory for Microbial Dynamics and Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, Oslo N-0316, Norway
Rune Slimestad
PlantChem, Særheim Research Center, N-4353 Klepp Station, Norway
Helle Wangensteen
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, Oslo N-0316, Norway
Karl E. Malterud
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, Oslo N-0316, Norway
Hilde Barsett
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, Oslo N-0316, Norway
Many bacteria growing on surfaces form biofilms. Adaptive and genetic changes of the microorganisms in this structure make them resistant to antimicrobial agents. Biofilm-forming organisms on medical devices can pose serious threats to human health. Thus, there is a need for novel prevention and treatment strategies. This study aimed to evaluate the ability of Aronia melanocarpa extracts, subfractions and compounds to prevent biofilm formation and to inhibit bacterial growth of Escherichia coli and Bacillus cereus in vitro. It was found that several aronia substances possessed anti-biofilm activity, however, they were not toxic to the species screened. This non-toxic inhibition may confer a lower potential for resistance development compared to conventional antimicrobials.