Journal of Nanobiotechnology (May 2024)

Application and advances of biomimetic membrane materials in central nervous system disorders

  • Weiquan Liao,
  • Zhichao Lu,
  • Chenxing Wang,
  • Xingjia Zhu,
  • Yang Yang,
  • Youlang Zhou,
  • Peipei Gong

DOI
https://doi.org/10.1186/s12951-024-02548-8
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 17

Abstract

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Abstract Central nervous system (CNS) diseases encompass spinal cord injuries, brain tumors, neurodegenerative diseases, and ischemic strokes. Recently, there has been a growing global recognition of CNS disorders as a leading cause of disability and death in humans and the second most common cause of death worldwide. The global burdens and treatment challenges posed by CNS disorders are particularly significant in the context of a rapidly expanding global population and aging demographics. The blood-brain barrier (BBB) presents a challenge for effective drug delivery in CNS disorders, as conventional drugs often have limited penetration into the brain. Advances in biomimetic membrane nanomaterials technology have shown promise in enhancing drug delivery for various CNS disorders, leveraging properties such as natural biological surfaces, high biocompatibility and biosafety. This review discusses recent developments in biomimetic membrane materials, summarizes the types and preparation methods of these materials, analyzes their applications in treating CNS injuries, and provides insights into the future prospects and limitations of biomimetic membrane materials.

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