Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

Amit K. Subudhi; Aidan J. O’Donnell; Abhinay Ramaprasad; Hussein M. Abkallo; Abhinav Kaushik; Hifzur R. Ansari; Alyaa M. Abdel-Haleem; Fathia Ben Rached; Osamu Kaneko; Richard Culleton; Sarah E. Reece; Arnab Pain

doi:10.1038/s41467-020-16593-y

Nature Communications (Jun 2020)

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

Amit K. Subudhi,
Aidan J. O’Donnell,
Abhinay Ramaprasad,
Hussein M. Abkallo,
Abhinav Kaushik,
Hifzur R. Ansari,
Alyaa M. Abdel-Haleem,
Fathia Ben Rached,
Osamu Kaneko,
Richard Culleton,
Sarah E. Reece,
Arnab Pain

Affiliations

Amit K. Subudhi: Pathogen Genomics Group, BESE Division, King Abdullah University of Science and Technology (KAUST)
Aidan J. O’Donnell: Institute of Evolutionary Biology, and Institute of Immunology and Infection Research, University of Edinburgh
Abhinay Ramaprasad: Pathogen Genomics Group, BESE Division, King Abdullah University of Science and Technology (KAUST)
Hussein M. Abkallo: Malaria Unit, Department of Pathology, Institute of Tropical Medicine (NEKKEN), Nagasaki University
Abhinav Kaushik: Pathogen Genomics Group, BESE Division, King Abdullah University of Science and Technology (KAUST)
Hifzur R. Ansari: Pathogen Genomics Group, BESE Division, King Abdullah University of Science and Technology (KAUST)
Alyaa M. Abdel-Haleem: Pathogen Genomics Group, BESE Division, King Abdullah University of Science and Technology (KAUST)
Fathia Ben Rached: Pathogen Genomics Group, BESE Division, King Abdullah University of Science and Technology (KAUST)
Osamu Kaneko: Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University
Richard Culleton: Malaria Unit, Department of Pathology, Institute of Tropical Medicine (NEKKEN), Nagasaki University
Sarah E. Reece: Institute of Evolutionary Biology, and Institute of Immunology and Infection Research, University of Edinburgh
Arnab Pain: Pathogen Genomics Group, BESE Division, King Abdullah University of Science and Technology (KAUST)

DOI: https://doi.org/10.1038/s41467-020-16593-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The mechanism underlying periodicity of Plasmodium’s intra-erythrocytic developmental cycle (IDC) is unclear. Here, Subudhi et al. show that serpentine receptor 10 (SR10) plays a role in regulating the schedule of the IDC in line with the timing of host daily rhythms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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