Influence of the glutation S-transferases T1 and M1 gene polymorphisms on androgenic status and semen quality after surgical treatment of varicocele

Abstract

Aim: to examine androgenic status in men after surgical treatment of varicocele; to investigate genotype GSTT1 and GSTM1 in patients with pathozoospermia. Thirty men after surgical treatment of varicocele were recruited to this study. All subjects were evaluated by history, physical examination, semen analysis, serum FSH, LH, E2, PL, inhibin B and total testosterone determination. GSTT1, CSTM1 gene polymorphisms were determined by polymerase chain reaction. Total testosterone and inhibin B levels were significantly lower in patients with pathozoospermia. Patients with the GSTM1(-) genotype had lower sperm concentrations than those with the GSTM1(+) genotype.Our results suggest that the GSTM1(-) genotype is risk factor for androgen deficiency and pathozoospermia.

Keywords

• varicocele
• androgenic status
• gstt1
• gstm1 gene polymorphisms
• pathozoospermia