Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells

Aki Stubb; Camilo Guzmán; Elisa Närvä; Jesse Aaron; Teng-Leong Chew; Markku Saari; Mitro Miihkinen; Guillaume Jacquemet; Johanna Ivaska

doi:10.1038/s41467-019-12611-w

Nature Communications (Oct 2019)

Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells

Aki Stubb,
Camilo Guzmán,
Elisa Närvä,
Jesse Aaron,
Teng-Leong Chew,
Markku Saari,
Mitro Miihkinen,
Guillaume Jacquemet,
Johanna Ivaska

Affiliations

Aki Stubb: Turku Bioscience Centre, University of Turku and Åbo Akademi University
Camilo Guzmán: Turku Bioscience Centre, University of Turku and Åbo Akademi University
Elisa Närvä: Turku Bioscience Centre, University of Turku and Åbo Akademi University
Jesse Aaron: Advanced Imaging Center, HHMI Janelia Research Campus
Teng-Leong Chew: Advanced Imaging Center, HHMI Janelia Research Campus
Markku Saari: Turku Bioscience Centre, University of Turku and Åbo Akademi University
Mitro Miihkinen: Turku Bioscience Centre, University of Turku and Åbo Akademi University
Guillaume Jacquemet: Turku Bioscience Centre, University of Turku and Åbo Akademi University
Johanna Ivaska: Turku Bioscience Centre, University of Turku and Åbo Akademi University

DOI: https://doi.org/10.1038/s41467-019-12611-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Pluripotent stem cell colonies are encircled by large cornerstone focal adhesions (FAs). Here, using super-resolution imaging, the authors describe features in the nanoscale makeup of these stable FAs such as inverted vinculin, lateral talin segregation and distinct kank protein distributions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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