Influence of TLR4 signaling on cannabidiol’s antitumor effectiveness in lung adenocarcinoma cells

Abstract

Lung cancer remains a predominant cancer type with high incidence and low survival rates. Key challenges in its treatment include impaired cellular mechanisms, notably resistance to apoptosis and altered immune responses. A critical aspect in this context is the heightened TLR4-mediated signaling, known to promote cell survival, metastasis, and resistance to cell death, particularly impacting immune microenvironment regulation. This study focuses on evaluating the impact of TLR4 signaling activation on potential therapeutic strategies.

Keywords

• apoptosis
• cannabinoids
• cbd
• lung cancer
• tlr4