SPOP promotes cervical cancer progression by inducing the movement of PD-1 away from PD-L1 in spatial localization

Abstract

Highlights 1. The SPOP is associated with pelvic lymph node (pLN) metastasis and prognosis in cervical cancer (CC) patients. 2. This paper discusses the potential mechanism of pLN metastasis of CC from the perspective of spatial location. 3. This is a multi-cross study, including clinical data, tissue microarray (TMA), multicolor immunofluorescence (m-IF), spatial immunolocalization, in vitro and in vivo functional and mechanism research fusion, from clinical to basic and clinical research.

Keywords

• Cervical cancer
• SPOP
• Multiplex immunofluorescence
• PD-1/PD-L1 axis
• CXCL16/CXCR6 axis